28 articles for thisTarget
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The synthesis and biological evaluation of alkyl and benzyl naphthyridinium analogs of eupolauridine as potential antimicrobial and cytotoxic agents.
Southern Research Institute
Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.
Southern Research Institute
14-Alkoxy- and 14-acyloxypyridomorphinans:µ agonist/d antagonist opioid analgesics with diminished tolerance and dependence side effects.
Southern Research Institute
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Southern Research Institute
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Southern Research Institute
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Southern Research Institute
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Southern Research Institute
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.
Southern Research Institute
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
Southern Research Institute
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Southern Research Institute
Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
Southern Research Institute
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.
Southern Research Institute
Enhancement of nucleoside cytotoxicity through nucleotide prodrugs.
Southern Research Institute
Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β.
Southern Research Institute
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Southern Research Institute
Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.
Southern Research Institute
Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
Southern Research Institute
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
Southern Research Institute
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Southern Research Institute
Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
Southern Research Institute
Prodrugs of pyridone amides useful as modulators of sodium channels
Vertex Pharmaceuticals
Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
University of California San Francisco