BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 698K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

30 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part II.EBI
Biocryst Pharmaceuticals
Synthesis of a potent transition-state inhibitor of 5'-deoxy-5'-methylthioadenosine phosphorylase.EBI
Biocryst Pharmaceuticals
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.EBI
Biocryst Pharmaceuticals
Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.EBI
Biocryst Pharmaceuticals
Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I.EBI
Biocryst Pharmaceuticals
Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.EBI
Biocryst Pharmaceuticals
Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon.EBI
Biocryst Pharmaceuticals
Synthesis of a potent 5'-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor.EBI
Biocryst Pharmaceuticals
Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.EBI
Biocryst Pharmaceuticals
Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.EBI
Biocryst Pharmaceuticals
Compounds having tetrahydroindolizine-1-carboxamide as BCL-2 inhibitorsBDB
Eil Therapeutics
Fused pyrimidine pyridinone compounds as JAK inhibitorsBDB
Theravance Biopharma R&D Ip
Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitorsBDB
Astrazeneca
7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitorsBDB
Eli Lilly
Heterocyclic compounds and uses thereofBDB
Millennium Pharmaceuticals
Prodrugs of modulators of the NMDA receptorBDB
H. Lundbeck
Pyrrole tricyclic compounds as A2A / A2B inhibitorsBDB
Incyte
Alkyl substituted triazole compounds as agonists of the APJ ReceptorBDB
Amgen
Cyanoindoline derivatives as NIK inhibitorsBDB
Janssen Pharmaceutica
Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones as HPK1 antagonistsBDB
Nimbus Saturn
Heterocyclic compounds as RET kinase inhibitorsBDB
Cancer Research Technology
5-substituted indazole-3-carboxamides and preparation and use thereofBDB
Samumed
Macrocycles as PDE1 inhibitorsBDB
H. Lundbeck
Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetesBDB
Boehringer Ingelheim International
Pyrrolotriazine compounds as TAM inhibitorsBDB
Incyte
Pyrrolopyrimidine derivatives as TAM inhibitorsBDB
Incyte
Carbazole compounds useful as bromodomain inhibitorsBDB
Bristol-Myers Squibb
Substituted pyrrolo[3,4-d]pyrimidines as kinase inhibitorsBDB
Novartis
Histone deacetylase inhibitors and compositions and methods of use thereofBDB
Chdi Foundation
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.BDB
Bristol-Myers Squibb Pharmaceutical Research Institute