43 articles for thisTarget
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Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIß (PI4KB).
Academy of Sciences of The Czech Republic
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIß (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Academy of Sciences of The Czech Republic
Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.
Academy of Sciences of The Czech Republic
Neurosteroid-like Inhibitors of N-Methyl-d-aspartate Receptor: Substituted 2-Sulfates and 2-Hemisuccinates of Perhydrophenanthrene.
Academy of Sciences of The Czech Republic
Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
Academy of Sciences of The Czech Republic
Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
Academy of Sciences of The Czech Republic
Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Academy of Sciences of The Czech Republic
Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.
Academy of Sciences of The Czech Republic
Norbornane-based nucleoside and nucleotide analogues locked in North conformation.
Academy of Sciences of The Czech Republic
Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.
Academy of Sciences of The Czech Republic
The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Academy of Sciences of The Czech Republic
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.
Academy of Sciences of The Czech Republic
Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles.
Academy of Sciences of The Czech Republic
Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S-methyltransferase 2.
Academy of Sciences of The Czech Republic
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
Academy of Sciences of The Czech Republic
Activation of human RNase L by 2'- and 5'-O-methylphosphonate-modified oligoadenylates.
Academy of Sciences of The Czech Republic
N-phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase.
Academy of Sciences of The Czech Republic
Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.
Academy of Sciences of The Czech Republic
A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.
Academy of Sciences of The Czech Republic
2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.
Academy of Sciences of The Czech Republic
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
Academy of Sciences of The Czech Republic
Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.
Academy of Sciences of The Czech Republic
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Academy of Sciences of The Czech Republic
Synthesis and significant cytostatic activity of 7-hetaryl-7-deazaadenosines.
Academy of Sciences of The Czech Republic
Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.
Academy of Sciences of The Czech Republic
8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase.
Academy of Sciences of The Czech Republic
Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta.
Academy of Sciences of The Czech Republic
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Academy of Sciences of The Czech Republic
Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.
Academy of Sciences of The Czech Republic
HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site.
Academy of Sciences of The Czech Republic
S-alkylated homocysteine derivatives: new inhibitors of human betaine-homocysteine S-methyltransferase.
Academy of Sciences of The Czech Republic
Activation of murine RNase L by isopolar 2'-phosphonate analogues of 2',5' oligoadenylates.
Academy of Sciences of The Czech Republic
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
Academy of Sciences of The Czech Republic
Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly.
Academy of Sciences of The Czech Republic
Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.
Academy of Sciences of The Czech Republic
Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
Academy of Sciences of The Czech Republic
Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base.
Academy of Sciences of The Czech Republic
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.
Academy of Sciences of The Czech Republic
Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors
Janssen Pharmaceutica
The human liver fatty acid binding protein T94A variant alters the structure, stability, and interaction with fibrates.
Texas A&M University