12 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Design, synthesis, and biochemical evaluation of novel alpha V beta 3 integrin ligands.
3-Dimensional Pharmaceuticals
Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.
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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
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A novel series of potent and selective small molecule inhibitors of the complement component C1s.
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Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors.
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Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
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Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.
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Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.
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Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.
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Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor.
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Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.
3-Dimensional Pharmaceuticals