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Latest developments in coumarin-based anticancer agents: mechanism of action and structure-activity relationship studies.
RSC Med Chem 15: 10-54 (2024)
Csir-Central Glass & Ceramic Research Institute
Recent advances of phenotypic screening strategies in the application of anti-influenza virus drug discovery.
RSC Med Chem 15: 70-80 (2024)
Shandong University
Physicochemical characterization of
RSC Med Chem 15: 119-126 (2024)
Tokyo Medical and Dental University
Discovery of imidazo[1,2-
RSC Med Chem 15: 178-192 (2024)
Purdue University
Discovery of a dual-acting inhibitor of interleukin-1β and STATs for the treatment of inflammatory bowel disease.
RSC Med Chem 15: 193-206 (2024)
Guangzhou Medical University
Highly efficient, catalyst-free, one-pot sequential four-component synthesis of novel spiroindolinone-pyrazole scaffolds as anti-Alzheimer agents:
RSC Med Chem 15: 207-222 (2024)
Persian Gulf University
The development of thymol-isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity.
RSC Med Chem 15: 234-253 (2024)
Guru Nanak Dev University
A survey of stapling methods to increase affinity, activity, and stability of ghrelin analogues.
RSC Med Chem 15: 254-266 (2024)
University of Western Ontario
Novel indolyl 1,2,4-triazole derivatives as potential anti-proliferative agents:
RSC Med Chem 15: 293-308 (2024)
Misr International University
Scaffold hopping based designing of selective ALDH1A1 inhibitors to overcome cyclophosphamide resistance: synthesis and biological evaluation.
RSC Med Chem 15: 309-321 (2024)
Punjabi University
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.
RSC Med Chem 15: 344-354 (2024)
Idorsia Pharmaceuticals
Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules.
RSC Med Chem 15: 399-415 (2024)
University of Arkansas
Role of heterocycles in inhibition of VEGFR-2 - a recent update (2019-2022).
RSC Med Chem 15: 416-432 (2024)
Srmpp
Discovery of dual-action phenolic 4-arylidene-isoquinolinones with antioxidant and α-glucosidase inhibition activities.
RSC Med Chem 15: 519-538 (2024)
National Autonomous University of Mexico
Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.
RSC Med Chem 15: 539-552 (2024)
Zhejiang University
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.
RSC Med Chem 15: 607-611 (2024)
Dana-Farber Cancer Institute
Small molecule WDR5 inhibitors down-regulate lncRNA expression.
RSC Med Chem 15: 636-640 (2024)
Max Planck Institute of Molecular Physiology
Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents.
RSC Med Chem 15: 704-719 (2024)
Korea Research Institute of Chemical Technology
Consensus screening for a challenging target: the quest for P-glycoprotein inhibitors.
RSC Med Chem 15: 720-732 (2024)
The Scripps Research Institute
Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors.
RSC Med Chem 15: 733-752 (2024)
Health Affairs Directorate - Giza
Indole-containing pharmaceuticals: targets, pharmacological activities, and SAR studies.
RSC Med Chem 15: 788-808 (2024)
Tianjin University
The medicinal chemistry evolution of antibody-drug conjugates.
RSC Med Chem 15: 809-831 (2024)
Abbvi
-Arylsulfonamide-based adenosine analogues to target RNA cap
RSC Med Chem 15: 839-847 (2024)
University of Montpellier Cnrs
Discovery of benzoheterocyclic-substituted amide derivatives as apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
RSC Med Chem 15: 856-873 (2024)
South China University
Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues.
RSC Med Chem 15: 916-936 (2024)
Monash University
Molecular editing of
RSC Med Chem 15: 937-962 (2024)
National Institute of Pharmaceutical Education and Research (NIPER)
Design, synthesis and preliminary biological evaluation of rivastigmine-INDY hybrids as multitarget ligands against Alzheimer's disease by targeting butyrylcholinesterase and DYRK1A/CLK1 kinases.
RSC Med Chem 15: 963-980 (2024)
University of Rouen Normandy
Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.
RSC Med Chem 15: 981-997 (2024)
Ain-Shams University
Synthesis and bioactivity of psilocybin analogues containing a stable carbon-phosphorus bond.
RSC Med Chem 15: 998-1002 (2024)
Ghent University
Deconvoluting low yield from weak potency in direct-to-biology workflows with machine learning.
RSC Med Chem 15: 1015-1021 (2024)
University of Cambridge
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of
RSC Med Chem 15: 1022-1037 (2024)
Jamia Millia Islamia (A Central University)
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
RSC Med Chem 15: 1066-1071 (2024)
University of Toronto
Beyond inhibition against the PD-1/PD-L1 pathway: development of PD-L1 inhibitors targeting internalization and degradation of PD-L1.
RSC Med Chem 15: 1096-1108 (2024)
China Pharmaceutical University
Small molecules modulating RNA splicing: a review of targets and future perspectives.
RSC Med Chem 15: 1109-1126 (2024)
University of Bordeaux
Progress in small-molecule inhibitors targeting PD-L1.
RSC Med Chem 15: 1161-1175 (2024)
Henan University
1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists.
RSC Med Chem 15: 1210-1215 (2024)
University of Groningen
A novel BODIPY-based theranostic agent for
RSC Med Chem 15: 1216-1224 (2024)
Shanghai Institute of Materia Medica
Screening of efficient salicylaldoxime reactivators for DFP and paraoxon-inhibited acetylcholinesterase.
RSC Med Chem 15: 1225-1235 (2024)
Air Force Medical University
Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity.
RSC Med Chem 15: 1247-1257 (2024)
University of Florence
Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water.
RSC Med Chem 15: 1274-1282 (2024)
Kindai University
Design, synthesis,
RSC Med Chem 15: 1329-1347 (2024)
Central University of Punjab
Discovery of novel SOS1 inhibitors using machine learning.
RSC Med Chem 15: 1392-1403 (2024)
University of Nottingham Ningbo China
Helical sulfonyl-γ-AApeptides for the inhibition of HIV-1 fusion and HIF-1α signaling.
RSC Med Chem 15: 1418-1423 (0)
University of South Florida
SETDB1 as a cancer target: challenges and perspectives in drug design.
RSC Med Chem 15: 1424-1451 (0)
University of Sao Paulo
Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy.
RSC Med Chem 15: 1452-1470 (0)
Indian Institute of Technology
Imidazopyrimidine: from a relatively exotic scaffold to an evolving structural motif in drug discovery.
RSC Med Chem 15: 1488-1507 (0)
National Institute of Pharmaceutical Education and Research Ahmedabad (NIPER-A)
PDE-stable 2'3'-cGAMP analogues, containing 5'-S-phosphorothioester linkage, as STING agonists.
RSC Med Chem 15: 1508-1514 (0)
Purdue University
Coumarin-furo[2,3-d]pyrimidone hybrid molecules targeting human liver cancer cells: synthesis, anticancer effect, EGFR inhibition and molecular docking studies.
RSC Med Chem 15: 1565-1577 (0)
Hubei University
4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections.
RSC Med Chem 15: 1589-1600 (0)
Universite degli Studi di Parma Viale delle Scienze
Carltonine-derived compounds for targeted butyrylcholinesterase inhibition.
RSC Med Chem 15: 1601-1625 (0)
Charles University
Computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy.
RSC Med Chem 15: 1626-1639 (0)
Lupin Ltd.
A colorimetric assay adapted to fragment screening revealing aurones and chalcones as new arginase inhibitors.
RSC Med Chem 15: 1722-1730 (0)
Universite de Franche-Comte
Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria.
RSC Med Chem 15: 1731-1736 (0)
San Francisco State University
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes.
RSC Med Chem 15: 1773-1781 (0)
University of Cambridge
Unveiling sultam in drug discovery: spotlight on the underexplored scaffold.
RSC Med Chem 15: 1798-1827 (0)
Monash University
Small molecule targeted therapies for endometrial cancer: progress, challenges, and opportunities.
RSC Med Chem 15: 1828-1848 (0)
Yixing People's Hospital Yixing
Heterocyclic compounds as xanthine oxidase inhibitors for the management of hyperuricemia: synthetic strategies, structure-activity relationship and molecular docking studies (2018-2024).
RSC Med Chem 15: 1849-1876 (0)
ISF College of Pharmacy Ghal Kalan
Potential of covalently linked tamoxifen hybrids for cancer treatment: recent update.
RSC Med Chem 15: 1877-1898 (0)
American University of Ras Al Khaimah
Benzenesulfonamide decorated dihydropyrimidin(thi)ones: carbonic anhydrase profiling and antiproliferative activity.
RSC Med Chem 15: 1929-1941 (0)
Sinop University
Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-a]pyridine derivatives against MARK4 protein.
RSC Med Chem 15: 1942-1958 (0)
Indoan Institute of Technology
Design, synthesis and antibacterial activity evaluation of ebselen derivatives in NDM-1 producing bacteria.
RSC Med Chem 15: 1959-1972 (0)
Ocean University of China
Amine-containing donepezil analogues as potent acetylcholinesterase inhibitors with increased polarity.
RSC Med Chem 15: 2037-2044 (0)
University of New South Wales
Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer.
RSC Med Chem 15: 2045-2062 (0)
University of Bologna
Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-based derivatives as multitarget anti-Alzheimer agents.
RSC Med Chem 15: 2080-2097 (0)
King Faisal University
Identification of SARS-CoV-2 Mpro inhibitors through deep reinforcement learning for de novo drug design and computational chemistry approaches.
RSC Med Chem 15: 2146-2159 (0)
Johannes Gutenberg University
Discovery of aurones bearing two amine functionalities as SHIP2 inhibitors with insulin-sensitizing effect in rat myotubes.
RSC Med Chem 15: 2179-2195 (0)
Universiti Sains Malaysia
Rational design of small-sized peptidomimetic inhibitors disrupting protein-protein interaction.
RSC Med Chem 15: 2212-2225 (0)
Ningxia Medical University
Molecular understanding of the therapeutic potential of melanin inhibiting natural products.
RSC Med Chem 15: 2226-2253 (0)
Tianjin University
Design, synthesis, and anticancer assessment of structural analogues of (E)-1-((3,4,5-trimethoxybenzylidene)amino)-4-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]quinoxaline-2-carbonitrile (6b), an imidazo[1,2-a]quinoxaline-based non-covalent EGFR inhibitor.
RSC Med Chem 15: 2322-2339 (0)
Central University of Punjab
Impact of atropisomerism on a non-steroidal glucocorticoid receptor agonist.
RSC Med Chem 15: 2357-2371 (0)
WuXi AppTec
N-Sulfonylphenoxazines as neuronal calcium ion channel blockers.
RSC Med Chem 15: 2400-2412 (0)
Monash University
Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs.
RSC Med Chem 15: 2422-2439 (0)
George Washington University
Design and synthesis of chromene-1,2,3-triazole benzene sulfonamide hybrids as potent carbonic anhydrase-IX inhibitors against prostate cancer.
RSC Med Chem 15: 2440-2461 (0)
Taibah University
Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activity.
RSC Med Chem 15: 2496-2507 (0)
National Center for Genetic Engineering and Biotechnology (BIOTEC)
Synthesis and in vitro evaluation of novel amino-phenylmethylene-imidazolone 5-HT2A receptor antagonists.
RSC Med Chem 15: 2508-2513 (0)
Independent Researcher
Synthesis of a new series of 4-pyrazolylquinolinones with apoptotic antiproliferative effects as dual EGFR/BRAFV600E inhibitors.
RSC Med Chem 15: 2538-2552 (0)
Princess Nourah bint Abdulrahman University
Discovery of new 1,3-diphenylurea appended aryl pyridine derivatives as apoptosis inducers through c-MET and VEGFR-2 inhibition: design, synthesis, in vivo and in silico studies.
RSC Med Chem 15: 2553-2569 (0)
Tanta University
Recent insights of PROTAC developments in inflammation-mediated and autoimmune targets: a critical review.
RSC Med Chem 15: 2585-2600 (0)
National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad
New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages.
RSC Med Chem 15: 2692-2708 (0)
Cairo University
Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives.
RSC Med Chem 15: 2729-2744 (0)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)
Discovery of novel coumarin triazolyl and phenoxyphenyl triazolyl derivatives targeting amyloid beta aggregation-mediated oxidative stress and neuroinflammation for enhanced neuroprotection.
RSC Med Chem 15: 2745-2765 (0)
Mahidol University
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
RSC Med Chem 15: 2806-2825 (0)
University of Pisa
Antitubercular evaluation of dihydropyridine-triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions.
RSC Med Chem 15: 2867-2881 (0)
CSIR-Central Drug Research Institute
Phenylstyrylpyrimidine derivatives as potential multipotent therapeutics for Alzheimer's disease.
RSC Med Chem 15: 2922-2936 (0)
Central University of Punjab