Compile Data Set for Download or QSAR
Report error Found 203 of affinity data for UniProtKB/TrEMBL: Q9Y6F1
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167420(US9073893, 20)
Affinity DataKd:  50nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167421(US9073893, 21)
Affinity DataKd:  40nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167422(US9073893, 22)
Affinity DataKd:  270nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240704(US9422243, 1)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240707(US9422243, 4)
Affinity DataKd:  90nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240711(US9422243, 8)
Affinity DataKd:  30nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240712(US9422243, 10)
Affinity DataKd:  70nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240713(US9422243, 11)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240714(US9422243, 12)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240715(US9422243, 13)
Affinity DataKd:  34nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240716(US9422243, 14)
Affinity DataKd:  10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240717(US9422243, 15)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240718(US9422243, 18)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240719(US9422243, 19)
Affinity DataKd:  20nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240720(US9422243, 20)
Affinity DataKd: <10nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM240721(US9422243, 21)
Affinity DataKd:  50nMAssay Description:The identification of compounds capable of binding several PARP proteins is carried out through a screening method including the steps of a) provi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50226518(3-aminobenzoic acid | 3-Aminobenzoesaeure | m-Amin...)
Affinity DataKd: >2.00E+3nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50277614(2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]py...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27497(2-Dimethylamino-N-(6-oxo-5,6-dihydro-phenanthridin...)
Affinity DataKd:  700nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataKd:  70nMAssay Description:Binding affinity to human PARP3 PARP domain by isothermal titration colorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM124950(US8765972, 3)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM124951(US8765972, 4)
Affinity DataKd: >1.00E+4nMAssay Description:Displacement of fluorescent probe from human recombinant His/GST-tagged PARP3 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  5.80nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataKd:  267nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib)
Affinity DataKd:  24nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM209932(Veliparib | 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-be...)
Affinity DataKd:  231nMAssay Description:Binding affinity to PARP3 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50628429(CHEMBL5402698)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PARP3 (unknown origin) using biotinylated NAD+ as substrate by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM207617(US9260440, 62 | US9617273, Example 62)
Affinity DataIC50: 18nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP3 (2 to 540(end) residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50499821(CHEMBL3740104)
Affinity DataIC50: 46nMAssay Description:Inhibition of PARP3 (unknown origin) using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 46nMAssay Description:Inhibition of PARP3 (unknown origin) using activated DNA as substrate after 1 hr by streptavidin-horseradish peroxidase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50306253(1-(2-(pyridin-3-yl)acetyl)-2,3,9,9a-tetrahydro-1H-...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50630273(CHEMBL5403305)
Affinity DataIC50: 51nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged PARP3 (2 to 540(end) residues) expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 55nMAssay Description:Inhibition of PARP3 (unknown origin) using biotinylated NAD+ as substrate by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50145156(CHEMBL3764816)
Affinity DataIC50: 63nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50145156(CHEMBL3764816)
Affinity DataIC50: 63nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM206061(US9255106, S3)
Affinity DataIC50: 66.9nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataIC50: 68nMAssay Description:Inhibition of PARP-3 (unknown origin) pre-incubated for 30 mins before addition of activated DNA and NAD by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM50306256(1-(3-(pyrazin-2-yl)propanoyl)-2,3,9,9a-tetrahydro-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of PARP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50593627(CHEMBL5199558)
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal GST-fused human recombinant PARP3 (2 to 540 residues) expressed in Sf9 insect cells by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM207564(US9260440, 9 | US9617273, Example 9 | US10501467, ...)
Affinity DataIC50: 136nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

LigandPNGBDBM207602(US9260440, 47 | US9617273, Example 47 | US10501467...)
Affinity DataIC50: 180nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

LigandPNGBDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataIC50: 185nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

LigandPNGBDBM207556(US9260440, 1 | US9617273, Example 1 | US10501467, ...)
Affinity DataIC50: 199nMAssay Description:PARP-2 and PARP-3 enzymatic assays were conducted using commercial PARP-2/PARP-3 Chemiluminescent Assay Kit (BPS Biosciences) and the protocols with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
1/9/2017
Entry Details
Go to US Patent

TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 229nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 230nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataIC50: 295nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50316226(MK-4827 | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-inda...)
Affinity DataIC50: 296nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3 [R100H](Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataIC50: 320nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details
Go to US Patent

Displayed 1 to 50 (of 203 total ) | Next | Last >>
Jump to: