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Report error Found 27 of affinity data for UniProtKB/TrEMBL: Q9Y5A9
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601384(CHEMBL5205586)
Affinity DataIC50: 1.61E+5nMAssay Description:Binding affinity to GST-tagged YTHDF2 m6A-reader domain (unknown origin) using RRACH-containing methylated oligoRNA incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601386(CHEMBL5201513)
Affinity DataIC50: 1.61E+5nMAssay Description:Inhibition of YTHDF2 YTH domain (unknown origin) (383 to 579 residues) expressed as Escherichia coli BL21 (DE3) Rosetta cells by HTFR based binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601385(CHEMBL5192478)
Affinity DataIC50: 1.74E+5nMAssay Description:Binding affinity to GST-tagged YTHDF2 m6A-reader domain (unknown origin) using RRACH-containing methylated oligoRNA incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601383(CHEMBL5177286)
Affinity DataIC50: 1.74E+5nMAssay Description:Inhibition of YTHDF2 YTH domain (unknown origin) (383 to 579 residues) expressed as Escherichia coli BL21 (DE3) Rosetta cells by HTFR based binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601383(CHEMBL5177286)
Affinity DataIC50: 4.10E+5nMAssay Description:Binding affinity to GST-tagged YTHDF2 m6A-reader domain (unknown origin) using RRACH-containing methylated oligoRNA incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601385(CHEMBL5192478)
Affinity DataIC50: 4.10E+5nMAssay Description:Inhibition of YTHDF2 YTH domain (unknown origin) (383 to 579 residues) expressed as Escherichia coli BL21 (DE3) Rosetta cells by HTFR based binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601384(CHEMBL5205586)
Affinity DataIC50: 4.91E+5nMAssay Description:Inhibition of YTHDF2 YTH domain (unknown origin) (383 to 579 residues) expressed as Escherichia coli BL21 (DE3) Rosetta cells by HTFR based binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50601386(CHEMBL5201513)
Affinity DataIC50: 4.91E+5nMAssay Description:Binding affinity to GST-tagged YTHDF2 m6A-reader domain (unknown origin) using RRACH-containing methylated oligoRNA incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624885(US20230322715, Compound TR-YTH-05)
Affinity DataKi:  0.0700nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624887(US20230322715, Compound TR-YTH-07)
Affinity DataKi:  0.0770nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624883(US20230322715, Compound TR-YTH-03)
Affinity DataKi:  0.0850nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624898(US20230322715, Compound TR-YTH-18)
Affinity DataKi:  0.0950nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624884(US20230322715, Compound TR-YTH-04)
Affinity DataKi:  0.100nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624881(US20230322715, Compound TR-YTH-01)
Affinity DataKi:  0.102nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624890(US20230322715, Compound TR-YTH-10)
Affinity DataKi:  0.106nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624900(US20230322715, Compound TR-YTH-19)
Affinity DataKi:  0.107nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624894(US20230322715, Compound TR-YTH-14)
Affinity DataKi:  0.128nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624895(US20230322715, Compound TR-YTH-15)
Affinity DataKi:  0.145nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624893(US20230322715, Compound TR-YTH-13)
Affinity DataKi:  0.150nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624889(US20230322715, Compound TR-YTH-09)
Affinity DataKi:  0.172nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624896(US20230322715, Compound TR-YTH-16)
Affinity DataKi:  0.179nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624882(US20230322715, Compound TR-YTH-02)
Affinity DataKi:  0.182nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624901(US20230322715, Compound TR-YTH-20)
Affinity DataKi:  0.266nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624897(US20230322715, Compound TR-YTH-17)
Affinity DataKi:  0.333nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624886(US20230322715, Compound TR-YTH-06)
Affinity DataKi:  0.395nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624892(US20230322715, Compound TR-YTH-12)
Affinity DataKi:  0.850nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetYTH domain-containing family protein 2(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM624891(US20230322715, Compound TR-YTH-11)
Affinity DataKi:  5.59nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent