Compile Data Set for Download or QSAR
Report error Found 54 of affinity data for UniProtKB/TrEMBL: Q9UPY5
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126160(CHEMBL3629669)
Affinity DataIC50: 4nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126156(CHEMBL3629579)
Affinity DataIC50: 10nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126159(CHEMBL3629668)
Affinity DataIC50: 10nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126155(CHEMBL3629578)
Affinity DataIC50: 20nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126153(CHEMBL3629576)
Affinity DataIC50: 30nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126162(CHEMBL3629671)
Affinity DataIC50: 30nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126154(CHEMBL3629577)
Affinity DataIC50: 40nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126152(CHEMBL3629575)
Affinity DataIC50: 60nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126161(CHEMBL3629670)
Affinity DataIC50: 100nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50: 140nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataIC50: 160nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50: 200nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50: 200nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126157(CHEMBL3629580)
Affinity DataIC50: 300nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50126151(CHEMBL3629574)
Affinity DataIC50: 800nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50053588(4-((S)-Amino-carboxy-methyl)-benzoic acid | CHEMBL...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM17660(2-amino-3-(3,5-dioxo[1,2,4]oxadiazolidin-2-yl)prop...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50053588(4-((S)-Amino-carboxy-methyl)-benzoic acid | CHEMBL...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM17663((2S)-2-amino-3-(sulfooxy)propanoic acid | L-serine...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50097125(Salazosulfapyridine | 2-Hydroxy-5-((4-((2-pyridiny...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355004(CHEMBL1834956)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355002(CHEMBL1834954)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50220147(L-homocysteic acid | L-Homocysteate | (S)-2-amino-...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of amino acid transport system xc-More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355002(CHEMBL1834954)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355004(CHEMBL1834956)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355009(CHEMBL1614646)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355007(CHEMBL1834959)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50109609(L-cysteine | (2R)-2-amino-3-mercaptopropanoic acid...)
Affinity DataIC50: 1.16E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378666(CHEMBL601837)
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378667(CHEMBL604574)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355011(CHEMBL1834962)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355010(CHEMBL1834961)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378668(CHEMBL606915)
Affinity DataIC50: 2.25E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355012(CHEMBL1834963)
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378665(CHEMBL590556)
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of amino acid transport system xc- in human SNB19 cells assessed as [3H]L-glutamate uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataIC50: 4.50E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50103596(CHEBI:9334 | Azulfidine | Azulfidine EN | Azulfidi...)
Affinity DataIC50: 4.60E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355006(CHEMBL1834958)
Affinity DataIC50: 7.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355006(CHEMBL1834958)
Affinity DataIC50: 7.00E+5nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355003(CHEMBL1834955)
Affinity DataIC50: 9.00E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355008(CHEMBL1834960)
Affinity DataIC50: 9.20E+5nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355008(CHEMBL1834960)
Affinity DataIC50: 9.20E+5nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355001(CHEMBL1834953)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM60918(5-Amino-2-hydroxy-benzoic acid | cid_4075 | MLS001...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM39340(MLS000069725 | cid_5336 | SMR000058213 | SULFAPYRI...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM82251((S)-4CPG | CAS_134052-68-9 | (R)-4-Carboxyphenylgl...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50355005(CHEMBL1834957)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of xc-cystine-glutamate antiporter-mediated cystine uptake in human U87 cells using L-[14C]cystine as substrate after 15 mins by liquid sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378670(CHEMBL600474)
Affinity DataKi:  5.20E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50109609(L-cysteine | (2R)-2-amino-3-mercaptopropanoic acid...)
Affinity DataKi:  5.90E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCystine/glutamate transporter(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50378666(CHEMBL601837)
Affinity DataKi:  6.00E+4nMAssay Description:Competitive inhibition of [3H]L-glutamate uptake at amino acid transport system xc- in human SNB19 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
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