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Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataKd:  1nMAssay Description:Binding affinity towards antiestrogen binding site AEBSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407454(CHEMBL5281526)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50396754(CHEMBL2172347)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM20607((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50020285(CHEMBL955 | 3'-Methoxy-4'Hydroxyclomiphene | 4-{2-...)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411320(CHEMBL222694)
Affinity DataIC50: 30nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411320(CHEMBL222694)
Affinity DataIC50: 30nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407452(CHEMBL5284923)
Affinity DataIC50: 30nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50020286(CHEMBL292185 | 4-{1-Chloro-2-[4-(2-diethylamino-et...)
Affinity DataIC50: 32nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411320(CHEMBL222694)
Affinity DataIC50: 40nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411319(CHEMBL266892)
Affinity DataIC50: 50nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411320(CHEMBL222694)
Affinity DataIC50: 60nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411319(CHEMBL266892)
Affinity DataIC50: 70nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411319(CHEMBL266892)
Affinity DataIC50: 80nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50396753(CHEMBL2172349)
Affinity DataIC50: 120nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 150nMAssay Description:Growth inhibition of MDA-MB-435 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 200nMAssay Description:Growth inhibition of MCF7 cells expressing ER and antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 300nMAssay Description:Growth inhibition of MDA-MB-231 cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412080(CHEMBL342394)
Affinity DataIC50: 400nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50170646(CHEMBL2172263 | CHEMBL189871 | 4-(2-{4-[(E)-3-(4-C...)
Affinity DataIC50: 500nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412077((+)-PACHYSAMINE B)
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412082(CHEMBL455316)
Affinity DataIC50: 600nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407449(CHEMBL5285995)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407448(CHEMBL4454956)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50411319(CHEMBL266892)
Affinity DataIC50: 2.00E+3nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407451(CHEMBL5270628)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412076(CHEMBL457817)
Affinity DataIC50: 2.80E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412083(CHEMBL458033)
Affinity DataIC50: 3.50E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412081(CHEMBL505436)
Affinity DataIC50: 6.80E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50396752(CHEMBL2172350)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of 7-dehydroxycholesterol reductase-mediated cholesterol biosynthesis in human HL60 cells assessed as inhibition of 2-[13C]acetate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412079(CHEMBL456512)
Affinity DataIC50: 7.40E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50135147(N-[(5R,8S,9S,10R,13S,14S,17S)-17-((S)-1-Dimethylam...)
Affinity DataIC50: 8.00E+3nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 1.00E+4nMAssay Description:Growth inhibition of multidrug resistant MCF7/Adr cells containing antiestrogen binding sitesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50412078(EPIPACHYSAMINE D)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of [3H]tamoxifen from antiestrogen binding site in Sprague-Dawley rat liver by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407447(CHEMBL5285729)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target7-dehydrocholesterol reductase(Human)
The Feinberg School of Medicine of Northwestern University

Curated by ChEMBL
LigandPNGBDBM50407450(CHEMBL4544901)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DHCR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM707172(7-[2-[(5-Chloro-6-cyclohexyl-3- pyridyl)oxy]ethyl]...)
Affinity DataKi:  1.96nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707127(7-((1-(4- (Trifluoromethyl)phenoxy) cyclobutyl)met...)
Affinity DataKi:  3.70nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707051(6-(2,2-Dimethyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  4.02nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707064(7-(2-Methyl-2-(4- (trifluoromethyl)phenoxy)propyl)...)
Affinity DataKi:  5.04nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707025((R)-6-(3-(4-cyclobutylphenyl)-2- methylpropyl)-2-t...)
Affinity DataKi:  5.14nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707180(7-(2-((6-((trans)-4- (Trifluoromethyl)cyclohexyl) ...)
Affinity DataKi:  5.72nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707031((S)-6-(2-Methyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  5.85nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707024((R)-6-(3-(4-cyclobutylphenyl)-2- methylpropyl)-2-t...)
Affinity DataKi:  6.54nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707119(7-(2-(4- (Trifluoromethoxy)phenoxy)ethyl)- 2-thia-...)
Affinity DataKi:  6.54nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707080(7-(2,2-Dimethyl-3-(4- (trifluoromethyl)phenyl)prop...)
Affinity DataKi:  7.23nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707040((S)-6-(2-Methyl-3-(4- (trifluoromethoxy)phenyl)pro...)
Affinity DataKi:  7.27nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707152(7-(2-(4-Chloro-3- fluorophenoxy)-2- methylpropyl)-...)
Affinity DataKi:  7.31nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707134(7-(2-(3-Fluoro-4- (trifluoromethyl)phenoxy)ethyl)-...)
Affinity DataKi:  7.95nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

LigandPNGBDBM707018(6-3-(4-(2,2- Dimethylcyclopropyl)phenyl)-2- methyl...)
Affinity DataKi:  8.31nMAssay Description:Compounds were prepared in a 96-well U bottom plate using an Echo550 machine and 10 mM compound DMSO stock solution, followed by an 8-dose 5-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/16/2025
Entry Details
Go to US Patent

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