Compile Data Set for Download or QSAR
Report error Found 57 of affinity data for UniProtKB/TrEMBL: Q9R297
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataEC50:  410nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196456((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196447((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196454((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196458((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196460((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196450((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196449((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  340nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196461((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196448((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196445((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50:  29nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196459((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataEC50:  24nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataEC50:  1.10E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196453((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataEC50:  1.50E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196452((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196455((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at TRHR2 expressed in HEK293EM cells assessed as activation potency by measuring CREB-luciferase reporter activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataEC50:  1.30E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 23nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261174(corymbone B | CHEMBL496930)
Affinity DataIC50: 1.90E+4nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRH2 receptor expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 2.30E+4nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRH2 receptor expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261685(corymbone A | CHEMBL447346)
Affinity DataIC50: 2.30E+4nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRH2 receptor expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261331(20-Acetoxy-19-hydroxyspongia-13(16),14-diene | CHE...)
Affinity DataIC50: 2.30E+4nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261332(19-Acetoxy-20-hydroxyspongia-13(16),14-diene | CHE...)
Affinity DataIC50: 7.00E+4nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261333(19,20-Diacetoxyspongia-13(16),14-diene | CHEMBL466...)
Affinity DataIC50: 4.00E+5nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261358(19,20-Dihydroxyspongia-13(16),14-diene | CHEMBL512...)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50261359(spongia-13(16),14-diene | (3bR,5aS,9aS,9bR)-3b,6,6...)
Affinity DataIC50: 1.00E+6nMAssay Description:Displacement of [3H]3-methylhistidyl-TRH from rat recombinant TRHR2 expressed in HEK2935 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196451((2S)-1-{(2S)-3-(1-methyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196457((2S)-1-{(2S)-3-(1-ethyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196445((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi:  290nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataKi:  1.70E+4nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196449((2S)-1-{(2S)-3-(1-allyl-1H-4-imidazolyl)-2-[(2S)-6...)
Affinity DataKi:  2.10E+4nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196452((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196459((2S)-1-[(2S)-2-(2S)-6-oxohexahydro-2-pyridinylcarb...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196458((2S)-1-{(2S)-3-(1-benzyl-1H-4-imidazolyl)-2-[(2S)-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196461((2S)-1-[(2S)-2-(1R)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50196460((2S)-1-[(2S)-2-(1S)-3-oxocyclopentylcarboxamido]-3...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]N(1)-Me-His-TRH from TRHR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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