Affinity DataEC50: 1.90E+3nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+3nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 870nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 850nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 390nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 370nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 360nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 310nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 280nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 250nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 110nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 90nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMAssay Description:Inhibition of SphK1 in human WM266-4 cells assessed as inhibition of formation of [17C]-S1P formation after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 8.30E+3nMAssay Description:Activation of recombinant GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins by Cerenkov counting...More data for this Ligand-Target Pair
Affinity DataEC50: 5.70E+3nMAssay Description:Activation of recombinant GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins by Cerenkov counting...More data for this Ligand-Target Pair
Affinity DataKd: 5nMAssay Description:Binding affinity to SK1 (unknown origin) assessed as inhibition of sphingosine phosphorylationMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataEC50: >950nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >800nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >550nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >800nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >500nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 154nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 276nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 202nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrsMore data for this Ligand-Target Pair
Affinity DataEC50: 299nMAssay Description:Inhibition of human SphK1 expressed in Saccharomyces cerevisiae KYA1 assessed as yeast growth at 30 degreeC measured after 24 to 48 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in S1P formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
