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TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631855(CHEMBL4530216)
Affinity DataKd: >1.00E+6nMAssay Description:Binding affinity to ASH1L SET domain (2069 to 2288 residues) (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646359(CHEMBL5077328)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646359(CHEMBL5077328)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50631854(CHEMBL5410484)
Affinity DataIC50: 790nMAssay Description:Inhibition of N-terminal Mocr-tagged ASH1L (2069 to 2288 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646360(CHEMBL5085204)
Affinity DataIC50: 790nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646360(CHEMBL5085204)
Affinity DataIC50: 790nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50649321(CHEMBL4546073)
Affinity DataIC50: 4.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ASH1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ASH1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646357(CHEMBL4551717)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646357(CHEMBL4551717)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646358(CHEMBL4556344)
Affinity DataIC50: 2.30E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646358(CHEMBL4556344)
Affinity DataIC50: 2.35E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646356(CHEMBL4580008)
Affinity DataIC50: 5.00E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50646356(CHEMBL4580008)
Affinity DataIC50: 5.05E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase ASH1L(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50649322(CHEMBL5619490)
Affinity DataIC50: 7.20E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed