Compile Data Set for Download or QSAR
Report error Found 543 for UniProtKB: Q9NP56
LigandPNGBDBM116309(US8637528, OM69)
Affinity DataIC50: 4.80nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
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LigandPNGBDBM50381299(CHEMBL2019112)
Affinity DataIC50: 8nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM116310(US8637528, OM056)
Affinity DataIC50: 9.27nMpH: 8.0Assay Description:The assay method used was a scintillation proximity assay (SPA) (obtained from GE Healthcare, Product Code TRKQ7100), with [3H]-cGMP as the substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details
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LigandPNGBDBM607104(US11685745, Example 37)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607105(US11685745, Example 43)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607106(US11685745, Example 51)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607107(US11685745, Example 64)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607108(US11685745, Example 79)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607109(US11685745, Example 123)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607110(US11685745, Example 176)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607111(US11685745, Example 189)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607112(US11685745, Example 225)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607114(US11685745, Example 332)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607115(US11685745, Example 334)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607116(US11685745, Example 336)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607118(US11685745, Example 378)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607119(US11685745, Example 427)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607121(US11685745, Example 492)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607122(US11685745, Example 545)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607123(US11685745, Example 557)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM607124(US11685745, Example 581 | US11685745, Example 576)
Affinity DataIC50: 10nMAssay Description:PDE7 inhibition was determined by an IMAP TR-FRET assay using PDE7B. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, FAM-cAMP s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
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LigandPNGBDBM724675(N-((1r,4r)-4-(4-acetyl- piperazin-1-yl)cyclo- hexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724688(N-((1r,4r)-4-(4-acet- ylpiperazin-1-yl)- cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724689(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (4-isop...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724696(N-((1r,4r)-4-(3,3- difluoroazetidin-1- yl)cyclohex...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724703(N-((1r,4r)-4-(4-cyclo- propylpiperazin-1-yl)- cycl...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724705(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (3,3-di...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724706(N-((1r,4r)-4-(3,3- difluoropyrrolidin-1- yl)cycloh...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724709(N-((1r,4r)-4-(3,3- difluoroazetidin-1- yl)cyclohex...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724710(N-((1r,4r)-4-(4-iso- propylpiperazin-1- yl)cyclohe...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724711(3-methyl-N-((1r,4r)- 4-morpholinocyclo- hexyl)-1-n...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724715(N-((1r,4r)-4-(3- cyanoazetidin-1-yl)- cyclohexyl)-...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724716(N-((1r,4r)-4-(4-acet- ylpiperazin-1-yl)- cyclohexy...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724720(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (3-(dif...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724721(N-((1r,4r)-4-(3- (difluoromethoxy)- azetidin-1-yl)...)
Affinity DataIC50: 10nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM50397053(CHEMBL2171422)
Affinity DataIC50: 11nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50381291(CHEMBL2019104)
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50397052(CHEMBL2171423)
Affinity DataIC50: 19nMAssay Description:Inhibition of cloned human recombinant PDE7B assessed as [3H]cAMP hydrolysis by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM724673(1-(2-chlorophenyl)-3- methyl-N-((1r,4r)-4- morphol...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724678(1-(2-chlorophenyl)-N- ((1r,4r)-4-(3-(difluoro- met...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724682(1-(4,4-difluorocyclo- hexyl)-N-(3-(3,3- difluoropy...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724684(1-isobutyl-N-((1r,4r)- 4-(4-isopropylpiper- azin-1...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724690(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (4-(2,2...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724691(1-(4,4-difluorocyclo- hexyl)-N-((1r,4r)-4- (4-(2,2...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724692(1-(4,4-difluorocyclo- hexyl)-3-methyl-N- ((1r,4r)-...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724694(N-((1r,4r)-4-(4-cyclo- propylpiperazin-1- yl)cyclo...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724697(1-(4,4-difluorocyclo- hexyl)-3-methyl-N- ((1r,3r)-...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724707(N-((1r,4r)-4-(4-(2,2- difluoroethyl)piper- azin-1-...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724708(N-((1r,3r)-3-(4-acet- ylpiperazin-1-yl)- cyclobuty...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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LigandPNGBDBM724712(N-((1r,3r)-3-(4-cyclo- propylpiperazin-1- yl)cyclo...)
Affinity DataIC50: 20nMAssay Description:Compounds were tested for their activity by measuring the inhibition of PDE7A or PDE7B hydrolysis of [3H]cAMP to [3H]AMP. Generally, eight dilutions ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/30/2025
Entry Details
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