Compile Data Set for Download or QSAR
Report error Found 20 of affinity data for UniProtKB/TrEMBL: Q9JJX7
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 29nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 170nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 260nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 580nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 710nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 1.10E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2 [Q278R,I281T,K282R,P318T,Y321C](Mouse)
National Institutes of Health

LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 1.20E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 3.70E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 4.00E+3nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50179250(CHEMBL3813826)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 3.50E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 7.10E+4nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM188529(2,4-Dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]pyrimido[...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50438882(CHEMBL471342 | 10-Phenylpyrimido[4,5-b]quinoline-2...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50438870(CHEMBL2420501 | 8-Chloro-10-(4-hydroxyphenyl)pyrim...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50438865(CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50179183(CHEMBL576840 | NSC-3198)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50179184(CHEMBL264425)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of mouse recombinant TDP2 using alpha32P-cordycepin-3'-labeled TY19 as substrate after 15 mins by PAGE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2017
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 2(Mouse)
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50438863(CHEMBL2420465 | 10-(4-Hydroxyphenyl)-2,4-dioxo-pyr...)
Affinity DataIC50: 1.11E+5nMpH: 7.5Assay Description:TDP2 reactions were carried out as described previously23 with the following modifications. A 18-mer single-stranded oligonucleotide DNA substrate (&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2016
Entry Details Article
PubMed