Compile Data Set for Download or QSAR
Report error Found 144 of affinity data for UniProtKB/TrEMBL: Q9HCE7
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM41406(N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyra...)
Affinity DataEC50:  4.66E+3nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622674(CHEMBL1554836)
Affinity DataEC50: >2.20E+4nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622676(CHEMBL5430940)
Affinity DataEC50:  1.10E+3nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622677(CHEMBL5433058)
Affinity DataEC50:  600nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622678(CHEMBL5421627)
Affinity DataEC50:  250nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622679(CHEMBL5402761)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622680(CHEMBL5436232)
Affinity DataEC50:  580nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622681(CHEMBL5440935)
Affinity DataEC50:  410nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622682(CHEMBL5398156)
Affinity DataEC50:  2.50E+3nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622683(CHEMBL5426056)
Affinity DataEC50:  1.10E+3nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622684(CHEMBL5413507)
Affinity DataEC50:  230nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622685(CHEMBL5405373)
Affinity DataEC50:  40nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM238975(US9403833, 12 | US9403833, 10)
Affinity DataEC50:  316nMAssay Description:Stabilization of SMURF1 (unknown origin) assessed as decrease in auto-ubiquitination by measuring increase in protein level by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239101(US9403810, 2.2 | US10195181, Example 2.2)
Affinity DataIC50: 0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239132(US9403810, 22c)
Affinity DataIC50: 1.40nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50193010(CHEMBL3949800)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239117(US9403810, 22 | US10195181, Example 22c)
Affinity DataIC50: 1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239094(US9403810, 1.3 | US10195181, Example 1.3)
Affinity DataIC50: 1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239092(US9403810, 1.1 | US10195181, Example 1.1)
Affinity DataIC50: 2.10nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239092(US9403810, 1.1 | US10195181, Example 1.1)
Affinity DataIC50: 2.10nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239099(US9403810, 2 | US10195181, Example 2)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239099(US9403810, 2 | US10195181, Example 2)
Affinity DataIC50: 2.5nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239091(US9403810, 1 | US10195181, Example 1)
Affinity DataIC50: 2.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50193011(CHEMBL3945602)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239091(US9403810, 1 | US10195181, Example 1)
Affinity DataIC50: 2.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239095(US9403810, 1.4 | US10195181, Example 1.4)
Affinity DataIC50: 3.20nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239095(US9403810, 1.4 | US10195181, Example 1.4)
Affinity DataIC50: 3.20nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of N-terminal Prolabel-tagged human Smurf-1 HECT domain expressed in HEK293 cells assessed as accumulation of Smurf-1 protein using chemil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239105(US9403810, 6 | US10195181, Example 6)
Affinity DataIC50: 5.70nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239096(US9403810, 1.5 | US10195181, Example 1.5)
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239102(US9403810, 3 | US10195181, Example 3)
Affinity DataIC50: 6nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239096(US9403810, 1.5 | US10195181, Example 1.5)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239102(US9403810, 3 | US10195181, Example 3)
Affinity DataIC50: 6nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239097(US9403810, 1.6 | US10195181, Example 1.6)
Affinity DataIC50: 8nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239097(US9403810, 1.6 | US10195181, Example 1.6)
Affinity DataIC50: 8nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622684(CHEMBL5413507)
Affinity DataIC50: 11nMAssay Description:Inhibition of SMURF1 (unknown origin) assessed as self-ubiquitination by TR-FRET/biochemical assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239093(US9403810, 1.2 | US10195181, Example 1.2)
Affinity DataIC50: 14nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239093(US9403810, 1.2 | US10195181, Example 1.2)
Affinity DataIC50: 14nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239107(US9403810, 7 | US10195181, Example 7)
Affinity DataIC50: 19nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239107(US9403810, 7 | US10195181, Example 7)
Affinity DataIC50: 19nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239106(US9403810, 6.1 | US10195181, Example 6.1)
Affinity DataIC50: 23nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239106(US9403810, 6.1 | US10195181, Example 6.1)
Affinity DataIC50: 23nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM50622681(CHEMBL5440935)
Affinity DataIC50: 29nMAssay Description:Inhibition of SMURF1 (unknown origin) assessed as self-ubiquitination by TR-FRET/biochemical assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Human)
Novartis

US Patent
LigandPNGBDBM239098(US9403810, 1.7 | US10195181, Example 1.7)
Affinity DataIC50: 33nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase SMURF1(Human)
Novartis Institutes of Biomedical Research (NIBR)

Curated by ChEMBL
LigandPNGBDBM239098(US9403810, 1.7 | US10195181, Example 1.7)
Affinity DataIC50: 33nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

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