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Report error Found 24 of affinity data for UniProtKB/TrEMBL: Q9H2S1
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275157(N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-me...)
Affinity DataEC50:  1.40E+4nMAssay Description:Positive modulation of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50618500(CHEMBL5421015)
Affinity DataEC50:  1.80E+3nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275184(6,7-dichloro-3-(hydroxyimino)indolin-2-one | CHEMB...)
Affinity DataEC50:  800nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275183(1-ethyl-1H-benzo[d]imidazol-2(3H)-one | CHEMBL4528...)
Affinity DataEC50:  7.22E+5nMAssay Description:Positive modulation of SK2 in HEK293 cells in presence of Ca2+ by patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275090((1H-Benzoimidazol-2-yl)-(6,7-dichloro-1,2,3,4-tetr...)
Affinity DataKd:  47nMAssay Description:Inhibition of human SK2 channel by inside-out patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50263327(N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2...)
Affinity DataIC50: 59nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 123nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275960(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Affinity DataIC50: 530nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50264020(TCMDC-124275 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Affinity DataIC50: 543nMAssay Description:Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50275792(N-benzyl-5-chloropyrazolo[1,5-a]pyrimidin-7-amine ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of SK2 expressed in CHO FlipIn cells by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50507839(PF-6305591 | Pf-06305591)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356161(CHEMBL1909931)
Affinity DataKi:  90nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356159(CHEMBL1909929)
Affinity DataKi:  194nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50377863(AG-525 | CHEMBL257156)
Affinity DataKi:  277nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50241654((+)-berbamine | Berbamine | CHEMBL504323)
Affinity DataKi:  284nMAssay Description:Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50478473(CHEBI:49 | NSC-77037 | FANCHININ | Tetrandrine)
Affinity DataKi:  306nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356162(CHEMBL1909932)
Affinity DataKi:  397nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356158(CHEMBL1909928)
Affinity DataKi:  593nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50356160(CHEMBL1909930)
Affinity DataKi:  878nMAssay Description:Displacement of [125I]-apamin from cloned SK2 channel expressed in human HEK293 cells after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50626104(CHEMBL1182643)
Affinity DataKi:  1.26E+3nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50423643(CEPHARANTHINE)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [125I]apamin from human SK2 expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetSmall conductance calcium-activated potassium channel protein 2(Human)
Hebei Medical University

Curated by ChEMBL
LigandPNGBDBM50626105(CHEMBL1185254)
Affinity DataKi:  1.69E+3nMAssay Description:Displacement of [125I]apamin from SK2 (unknown origin) expressed in HEK293 cells assessed as inhibition constant incubated for 1 hr by liquid scintil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed