Compile Data Set for Download or QSAR
Report error Found 230 for UniProtKB: Q9BVC4
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataEC50:  0.25nMAssay Description:Inhibition of mTORC1 in human HCT116 cells assessed as reduction in T389 phosphorylation on RPS6KB1 after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  2.14E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616024(CHEMBL5420034)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616032(CHEMBL5429186)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616040(CHEMBL5418335)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616024(CHEMBL5420034)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616032(CHEMBL5429186)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606717(CHEMBL5218737)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 in human Jurkat cells assessed as inhibition of S6K phosphorylation incubated for 4 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606699(CHEMBL5220295)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606700(CHEMBL5218941)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606701(CHEMBL5219477)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606702(CHEMBL5219001)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606703(CHEMBL5219040)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616027(CHEMBL5430111)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616045(CHEMBL5422529)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616047(CHEMBL5441038)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616028(CHEMBL5404497)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616044(RMC-5552 | Rmc-5552)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616036(CHEMBL5419721)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616046(CHEMBL5399980)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606735(CHEMBL5219718 | US11731973, Example 3)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606736(CHEMBL5218916 | US11731973, Example 10)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616026(CHEMBL5430354)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616037(CHEMBL5413401)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616030(CHEMBL5408375)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616042(CHEMBL5422229)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616033(CHEMBL5404617)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616025(CHEMBL5427995)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616023(CHEMBL5440792)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50328584(1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethy...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616029(CHEMBL5394998)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606711(CHEMBL5220287)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606707(CHEMBL5220505)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606708(CHEMBL5220300)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606709(CHEMBL5219729)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606710(CHEMBL5219271)
Affinity DataIC50: 0.316nMAssay Description:Inhibition of mTORC1 in human PC-3 cells assessed as measuring phosphorylated S6K level incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616034(CHEMBL5419762)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616041(CHEMBL5431157)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616021(CHEMBL5422165)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616036(CHEMBL5419721)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616027(CHEMBL5430111)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616047(CHEMBL5441038)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616022(CHEMBL5425648)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616045(CHEMBL5422529)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in 4EBP1 phosphorylation at Thr37/46 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50616043(CHEMBL5434290)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of mTORC1 in human MDA-MB-468 cells assessed as reduction in P70S6K phosphorylation at Thr389 by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50606737(CHEMBL5218727 | US11731973, Example 5)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
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