Compile Data Set for Download or QSAR
Report error Found 888 of affinity data for UniProtKB/TrEMBL: Q99835
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50232973(CHEMBL254129 | CYCLOPAMINE)
Affinity DataKd:  12.4nMAssay Description:Binding affinity to wild type Smo expressed in U2OS cells by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388703(CHEMBL2057336)
Affinity DataEC50:  8nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388705(CHEMBL2059859)
Affinity DataEC50:  30nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388719(CHEMBL2059860)
Affinity DataEC50:  39.2nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388720(CHEMBL2059861)
Affinity DataEC50:  18nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388721(CHEMBL2059862)
Affinity DataEC50:  11nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388706(CHEMBL2059863)
Affinity DataEC50:  22nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388707(CHEMBL2059864)
Affinity DataEC50:  15nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  13nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388708(CHEMBL2059866)
Affinity DataEC50:  89nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388709(CHEMBL2059867)
Affinity DataEC50:  7nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388710(CHEMBL2059868)
Affinity DataEC50:  21nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388711(CHEMBL2059869)
Affinity DataEC50:  27nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388712(CHEMBL2059870)
Affinity DataEC50:  8nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388704(CHEMBL2059871)
Affinity DataEC50:  29nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388713(CHEMBL2059872)
Affinity DataEC50: >145nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388714(CHEMBL2059873)
Affinity DataEC50:  28nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388716(CHEMBL2059875)
Affinity DataEC50:  17nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388717(CHEMBL2059876)
Affinity DataEC50:  40nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388718(CHEMBL2057337)
Affinity DataEC50:  115nMAssay Description:Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataEC50:  2nMAssay Description:Binding affinity to human SMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50539187(CHEMBL4632769)
Affinity DataEC50:  0.5nMAssay Description:Binding affinity to human SMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50539188(CHEMBL4637222)
Affinity DataEC50:  1.5nMAssay Description:Binding affinity to human SMOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataEC50:  3nMAssay Description:Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataEC50:  130nMAssay Description:Displacement of BODIPY-labeled cyclopamine from human SMO transfected in human HeLa cells by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50544229(CHEMBL4633406)
Affinity DataKd:  1.21E+4nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataKd:  97.5nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50544230(CHEMBL4646026)
Affinity DataKd:  1.36E+4nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50544231(CHEMBL4637406)
Affinity DataKd:  10.3nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50544232(CHEMBL4645977)
Affinity DataKd:  10.6nMAssay Description:Binding affinity to recombinant human Smo receptor assessed as dissociation constant at equilibrium by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50324671(Purmorphamine | CHEMBL1221984)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at SMO receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50539187(CHEMBL4632769)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50539188(CHEMBL4637222)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320340((R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320341((R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50293788(N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S,7aR,12a'S,12b'...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant SMO expressed in mouse C3H10T1/2 cells assessed as inhibition of association of BODIPY-cyclopamineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320339((R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388706(CHEMBL2059863)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50388707(CHEMBL2059864)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50352418(CHEMBL1823863)
Affinity DataIC50: 3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Duke University Medical Center

Curated by ChEMBL
LigandPNGBDBM50320335((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
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