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TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50366480(ATP | ADENOSINE TRIPHOSPHATE)
Affinity DataEC50:  500nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50087267((S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-ox...)
Affinity DataEC50:  1.00E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118220(adenosine(5')tetraphospho(5')adenosine | P(1),P(4)...)
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118230(5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADEN...)
Affinity DataEC50:  2.50E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM85043(CHEMBL69234 | CAS_149017-66-3 | NSC_6093163 | PPAD...)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118232(ATP, 2-meS | CHEMBL336208 | 2-MeSATP)
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029031(CHEMBL223344 | 1-Amino-4-{4-[4-chloro-6-(3-sulfo-p...)
Affinity DataEC50:  1.28E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118219(Bz-ATP | CHEMBL339386)
Affinity DataEC50:  490nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118232(ATP, 2-meS | CHEMBL336208 | 2-MeSATP)
Affinity DataEC50:  1.00E+4nMAssay Description:Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50366480(ATP | ADENOSINE TRIPHOSPHATE)
Affinity DataEC50:  1.00E+3nMAssay Description:Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50596624(CHEMBL5204261)
Affinity DataEC50:  1.01E+4nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50596624(CHEMBL5204261)
Affinity DataEC50:  8.97E+3nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50596624(CHEMBL5204261)
Affinity DataEC50:  1.22E+4nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50598322(CHEMBL5200114)
Affinity DataEC50:  1.08E+4nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.05 uM incubated for 30 mins by Fura-2 AM s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50598322(CHEMBL5200114)
Affinity DataEC50:  1.01E+4nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.1 uM incubated for 30 mins by Fura-2 AM st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50598322(CHEMBL5200114)
Affinity DataEC50:  1.08E+4nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.2 uM incubated for 30 mins by Fura-2 AM st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50594505(CHEMBL5177316)
Affinity DataEC50:  1.48E+3nMAssay Description:Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50594506(CHEMBL5183218)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human P2X4R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506156(CHEMBL4471140)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506203(CHEMBL4452312)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506173(CHEMBL4589444)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506179(CHEMBL4579583)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506184(CHEMBL4447043)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506180(CHEMBL4556573)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506187(CHEMBL4522504)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506178(CHEMBL4555657)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506201(CHEMBL4516176)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506183(CHEMBL4521017)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506172(CHEMBL4563994)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506185(CHEMBL4438327)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366072(5-[4-[5-(2-Methoxybenzyl)-1H-tetrazol-1-yl]phenyl]...)
Affinity DataIC50: 25nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506191(CHEMBL4439570)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506169(CHEMBL4535761)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506162(CHEMBL4463320)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366073(5-[4-[5-(2-Hydroxybenzyl)-1H-tetrazol-1-yl]phenyl]...)
Affinity DataIC50: 37nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506157(CHEMBL4517831)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366069(US9873683, Example 79)
Affinity DataIC50: 39nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506198(CHEMBL4539658)
Affinity DataIC50: 39nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50598326(CHEMBL5206892)
Affinity DataIC50: 39nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50596624(CHEMBL5204261)
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation activity at human P2X4 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50540434(CHEMBL4640175)
Affinity DataIC50: 43nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366075(5-[4-(5-Phenethyl-1H-tetrazol-1-yl)phenyl]-1H-naph...)
Affinity DataIC50: 44nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506166(CHEMBL4474747)
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50430156(CHEMBL2338695)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM365870(US9873683, Example 31)
Affinity DataIC50: 51nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50506204(CHEMBL4443234)
Affinity DataIC50: 52nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366049(US9873683, Example 43)
Affinity DataIC50: 53nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM366062(US9873683, Example 67)
Affinity DataIC50: 53nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM393615(US09969700, 173)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at human P2X4 receptor expressed in HEK cells assessed as reduction in ATP induced calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50598322(CHEMBL5200114)
Affinity DataIC50: 55nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
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