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TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098250(CHEMBL3590389)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to KAT2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM249277(US9458145, 1020-18 | US10017501, Compound 1020-18)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system after 1 hr by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50453949(CHEMBL4208820 | US11247989, Example 87)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM179481(US9675697, Cpd. No. 73)
Affinity DataKd: >4.00E+3nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50512964(CHEMBL4574669)
Affinity DataKd:  105nMAssay Description:Binding affinity to human N-terminal His-tagged GCN5 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged GCN5L2 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50366670(CHEMBL4173488)
Affinity DataKd: >5.00E+3nMAssay Description:Binding affinity to human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514858(CHEMBL4577486)
Affinity DataKd:  501nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  251nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  158nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM220447(US9296741, 36 | US10633379, Compound X)
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity to human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Affinity DataKd:  44nMAssay Description:Binding affinity to GCN5L2 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50615275(CHEMBL5282240)
Affinity DataKd:  410nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM321437((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Affinity DataKd:  160nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50615276(CHEMBL5270178)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM321424(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to KAT2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098305(CHEMBL3590405)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to KAT2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50028142(CHEMBL2177300)
Affinity DataIC50: 316nMAssay Description:Inhibition of human GCN5 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256397(CHEMBL4088466)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM342597(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50: 8.39E+3nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346554(CHEMBL106011)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged human GCN5 expressed in a Baculovirus-infected Sf9 cell expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50506380(CHEMBL4587968 | US20240122941, Compound 15)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50200384(CHEMBL3968533 | US9763922, Example 299)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50200385(CHEMBL3959584)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50269847(CHEMBL4097025)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged human GCN5L2 measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50269849(CHEMBL4076748)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged human GCN5L2 measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50580965(CHEMBL5090239)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151658(CHEMBL3775671)
Affinity DataIC50: 3.39E+4nMAssay Description:Inhibition of GCN5 (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic screen in presence of [3H]ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50240436(2-hydroxy-6-pentadecylbenzoic acid | 6-(pentadecen...)
Affinity DataIC50: 4.21E+4nMAssay Description:Inhibition of recombinant human KAT2A (323 to 837 residues) using histone H3 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 4.74E+4nMAssay Description:Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50616185(CHEMBL5438086)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin) biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr in presence of acetyl-coA by AlphaLISA assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50600305(CHEMBL5193672)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50579801(CHEMBL5088992)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50579798(CHEMBL5080324)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCN5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50158627(CHEMBL3787482 | US10023592, Example 81)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human GCN5L2 by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346559(CHEMBL1795624)
Affinity DataIC50: 8.74E+4nMAssay Description:Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238541(CHEMBL4092336)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GCN5 (unknown origin) using H3 as substrate and Ac-CoA as cofactor preincubated for 10 mins followed by substrate/cofactor addition mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2019
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50371233(CHEMBL3347571)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GCN5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467835(CHEMBL217676)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged Gcn5 using H3 as substrate in presence of [3H]-acetyl-CoA by phosphor image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151657(CHEMBL3775750)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged GCN5 expressed in bacterial system using histone H3 as substrate preincubated for 20 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50467835(CHEMBL217676)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GCN5 using histone peptide as substrate in presence of [14C]-acetyl CoA by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone acetyltransferase KAT2A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to human partial length GCN5 expressed in bacterial expression system by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)