Compile Data Set for Download or QSAR
Report error Found 1647 of affinity data for UniProtKB/TrEMBL: Q8N884
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648831(CHEMBL5612485)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648831(CHEMBL5612485)
Affinity DataIC50: 1nMAssay Description:Inhibition of cGAS in dsDNA stimulated human Whole blood cell by measuring IFNalpha-2a production incubated for 60 mins followed by addition of doubl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700823(US20240342186, Example 2.04)
Affinity DataIC50: 1nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648829(CHEMBL5614320)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685892(US12043625, Example 3.01)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685893(US12043625, Example 3.02)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685857(US12043625, Example 1.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700795(US20240342186, Example 1.11)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700793(US20240342186, Example 1.09)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700824(US20240342186, Example 2.05)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685878(US12043625, Example 2.07)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685859(US12043625, Example 1.13 | US12043625, Ex. 1.13)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700804(US20240342186, Example 1.20)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685874(US12043625, Example 2.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50649732(CHEMBL5620249)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length his-tagged human recombinant cGAS extracted from Escherichia coli BL21 (DE3) incubated for 3 hrs by rapidfire 365 mass spec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685851(US12043625, Ex. 1.05 | US12043625, Example 1.05)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685882(US12043625, Example 2.11)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688400(US20240189315, Ex. 4.04 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 2nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685849(US12043625, Example 1.03)
Affinity DataIC50: 2nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648831(CHEMBL5612485)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50651824(CHEMBL5641551)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of cyclic GMP-AMP synthase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648827(CHEMBL5612416)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648829(CHEMBL5614320)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688363(US20240189315, Example 11)
Affinity DataIC50: 2.80nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648826(CHEMBL5614182)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of N-terminal 6His-SUMO tagged human cGAS (1 to 522 residues) extracted from Escherichia coli BL21(DE3)pLysS cells using GTP/ATP as substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM50648826(CHEMBL5614182)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of cGAS in human THP-1 cells expressed in baculovirus infected insect cells incubated for 18 hrs by Lucia luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700822(US20240342186, Example 2.03)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700817(US20240342186, Example 1.33)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700818(US20240342186, Example 1.34)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700815(US20240342186, Example 1.31)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700829(US20240342186, Example 2.10)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700827(US20240342186, Example 2.08)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700826(US20240342186, Example 2.07)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685872(US12043625, Example 2.01)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688392(US20240189315, Example 38)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700800(US20240342186, Example 1.16)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688391(US20240189315, Example 37)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685883(US12043625, Example 2.12 | US12043625, Ex. 2.12)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700814(US20240342186, Example 1.30)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM688404(US20240189315, Ex. 1.12 of PCT/EP2022/062480) | US...)
Affinity DataIC50: 3nMAssay Description:in vitro human biochemical cGAS inhibition.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM700812(US20240342186, Example 1.28)
Affinity DataIC50: 3nMAssay Description:Compounds were delivered in 10 mM DMSO solution, serially diluted and transferred to the 384 well assay plate (Greiner #781201) using an Echo acousti...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
Go to US Patent

TargetCyclic GMP-AMP synthase(Human)
PI Health Sciences

Curated by ChEMBL
LigandPNGBDBM685881(US12043625, Example 2.10)
Affinity DataIC50: 3nMAssay Description:PKC-theta and PKC-delta biochemical activities were measured using the PKC-theta HTRF KinEASEkit kit, according to manufacturer's instructions (C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2024
Entry Details
Go to US Patent

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