Compile Data Set for Download or QSAR
Report error Found 118 of affinity data for UniProtKB/TrEMBL: Q8JZL2
LigandPNGBDBM50383522(CHEMBL2032049)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at mouse MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50162116(2-(4-(benzyloxy)phenyl)-N-(1-(2-(pyrrolidin-1-yl)e...)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against Melanin-concentrating hormone receptor 1 in diet-induced obese miceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167565(1-[1-(2-Isobutylamino-ethyl)-1H-indazol-5-yl]-3-(4...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167552(1-[1-(2-Cyclopentylamino-ethyl)-1H-indazol-5-yl]-3...)
Affinity DataIC50: 2.40nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168509(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 3nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM119755(US8685958, 5 | US8685958, 4)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50192518(1-(2-(3,4-dimethylphenoxy)-5-((2-(pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167554(1-(4-Phenoxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl...)
Affinity DataIC50: 5.90nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50159340(CHEMBL3786169)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159145(CHEMBL3786685)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50192531(1-(2-chlorophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50159341(CHEMBL3786346)
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM119758(US8685958, 8 | US8685958, 7)
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159339(CHEMBL3786841)
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50167561(1-[1-(3-Cyclopentylamino-propyl)-1H-indazol-5-yl]-...)
Affinity DataIC50: 8.5nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50159261(CHEMBL3787333)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159142(CHEMBL3786311)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159144(CHEMBL3787261)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50168517(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 10nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50159343(CHEMBL3787394)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159345(CHEMBL3785663)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159337(CHEMBL3787028)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50167567(1-(4-Phenoxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl...)
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50301708((Z)-1'-((6-((3,4-difluorophenyl)(ethoxyimino)methy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of mouse MCH1R receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50159342(CHEMBL3787134)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159238(CHEMBL3786272)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159141(CHEMBL3785343)
Affinity DataIC50: 14nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM119763(US8685958, 12)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50159236(CHEMBL3787170)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]Tyr13-MCH from mouse MCHR1 after 60 mins by microbeta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
LigandPNGBDBM50167556(1-(4-Phenoxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-ethyl...)
Affinity DataIC50: 19.8nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168519(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50192522(1-(4-bromophenyl)-3-(2-(3,4-dimethylphenoxy)-5-((2...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [125I]MCH binding to mouse MCHR1 expressed in HEK293 cells by HT-SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168536(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 30nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167558(1-[2-(4-Phenoxy-phenyl)-ethyl]-3-[1-(2-pyrrolidin-...)
Affinity DataIC50: 34.3nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167564(1-{1-[2-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-ethy...)
Affinity DataIC50: 38.7nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167568(1-(3-{5-[3-(4-Phenoxy-phenyl)-ureido]-indazol-1-yl...)
Affinity DataIC50: 40.6nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167550(1-(4-Benzyloxy-phenyl)-3-[1-(2-pyrrolidin-1-yl-eth...)
Affinity DataIC50: 41.3nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168508(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 50nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168506(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2...)
Affinity DataIC50: 50nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168511(3-Methoxy-N-[1-((E)-3-phenyl-allyl)-piperidin-4-yl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168526(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2...)
Affinity DataIC50: 60nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167557(1-(4-Phenoxy-benzyl)-3-[1-(2-pyrrolidin-1-yl-ethyl...)
Affinity DataIC50: 78.5nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167553(1-{1-[3-((S)-2-Methoxymethyl-pyrrolidin-1-yl)-prop...)
Affinity DataIC50: 82.9nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168509(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration required for functional antagonism of MCH mediated Ca+2 release competing human IMR32 cells receptor in a FLIPRTM based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168515(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2...)
Affinity DataIC50: 90nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168539(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 90nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168540(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-4-yl)-2...)
Affinity DataIC50: 90nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50167569(1-{1-[3-(4-Hydroxy-piperidin-1-yl)-propyl]-1H-inda...)
Affinity DataIC50: 91.5nMAssay Description:Inhibitory concentration against mouse Melanin-concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]MCHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168528(N-(1-Benzo[1,3]dioxol-5-ylmethyl-piperidin-3-yl)-3...)
Affinity DataIC50: 110nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50168530(3-Chloro-N-[1-((E)-3-phenyl-allyl)-piperidin-4-yl]...)
Affinity DataIC50: 110nMAssay Description:Inhibition of binding to MCHR1 of human neuronal IMR32-derived cell-line I3.4.2 (Galpha-16 transfected)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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