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TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  2.00E+3nMAssay Description:Thermal stabilization of recombinant METTL3 (354 to 580 residues) (unknown origin) expressed in HEK293T cells assessed as non-aggregated METTL3-ePL p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50586498(CHEMBL5077332 | US20240139189, Compound 22)
Affinity DataEC50:  850nMAssay Description:Thermal stabilization of endogenously expressing full length METTL3 in human MOLM-13 cells assessed as stabilized METTL3 incubated for at 54 degC by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataKd:  4.80nMAssay Description:Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to METTL3 (unknown origin) by SPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50248106(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Affinity DataKd:  1.32E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataKd:  4.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50647912(PHENYL(METHYL)THIOSEMICARBAZONE)
Affinity DataKd:  3.31E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
University of Zurich

Curated by ChEMBL
LigandPNGBDBM50647913(CHEMBL5597626)
Affinity DataKd:  2.84E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756113(US20250214997, Compound E-57)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756156(US20250214997, Compound E-100)
Affinity DataIC50: 0.120nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756142(US20250214997, Compound E-86)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756175(US20250214997, Compound E-122)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756188(US20250214997, Compound E-140)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756143(US20250214997, Compound E-87)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756174(US20250214997, Compound E-121)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756140(US20250214997, Compound E-84)
Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756167(US20250214997, Compound E-111)
Affinity DataIC50: 0.240nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756107(US20250214997, Compound E-51)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756157(US20250214997, Compound E-101)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756106(US20250214997, Compound E-50)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756161(US20250214997, Compound E-105)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756172(US20250214997, Compound E-119)
Affinity DataIC50: 0.290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756070(US20250214997, Compound E-14)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756170(US20250214997, Compound E-114)
Affinity DataIC50: 0.310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756112(US20250214997, Compound E-56)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756121(US20250214997, Compound E-65)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756189(US20250214997, Compound E-141)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756105(US20250214997, Compound E-49)
Affinity DataIC50: 0.370nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756111(US20250214997, Compound E-55)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756144(US20250214997, Compound E-88)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756160(US20250214997, Compound E-104)
Affinity DataIC50: 0.410nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756162(US20250214997, Compound E-106)
Affinity DataIC50: 0.480nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756165(US20250214997, Compound E-109)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756135(US20250214997, Compound E-79)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756086(US20250214997, Compound E-30)
Affinity DataIC50: 0.560nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756115(US20250214997, Compound E-59)
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756082(US20250214997, Compound E-26)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756079(US20250214997, Compound E-23)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756169(US20250214997, Compound E-113)
Affinity DataIC50: 0.740nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756057(US20250214997, Compound E-1)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756095(US20250214997, Compound E-39)
Affinity DataIC50: 0.75nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756190(US20250214997, Compound E-143)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756083(US20250214997, Compound E-27)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756065(US20250214997, Compound E-9)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756125(US20250214997, Compound E-69)
Affinity DataIC50: 1.02nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756120(US20250214997, Compound E-64)
Affinity DataIC50: 1.06nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
Go to US Patent

TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756159(US20250214997, Compound E-103)
Affinity DataIC50: 1.09nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756089(US20250214997, Compound E-33)
Affinity DataIC50: 1.17nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756114(US20250214997, Compound E-58)
Affinity DataIC50: 1.18nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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TargetN6-adenosine-methyltransferase catalytic/non-catalytic subunit(Human)
Global Health Drug Discovery Institute

US Patent
LigandPNGBDBM756078(US20250214997, Compound E-22)
Affinity DataIC50: 1.21nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/23/2025
Entry Details
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