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Report error Found 23 for UniProtKB: Q62868
TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148425(US9682963, 13)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148423(US9682963, 12)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148421(US9682963, 11)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148407(US9682963, 1)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148408(US9682963, 2)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148409(US9682963, 3)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148410(US9682963, 4)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148412(US9682963, 5)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148413(US9682963, 6)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148414(US9682963, 7)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148415(US9682963, 8)
Affinity DataEC50:  550nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1/2(Rat)
Redx Pharma

US Patent
LigandPNGBDBM148416(US9682963, 9)
Affinity DataEC50: <100nMAssay Description:Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50614317(CHEMBL5281208)
Affinity DataIC50: 240nMAssay Description:Inhibition of ROCK2 in rat A7R5 cells assessed as MLC phosphorylation at T18/S19 by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataIC50: 270nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM14029(4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-...)
Affinity DataIC50: 800nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 820nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM163433(US9687483, 1 | BA-1049 | US11198680, Compound BA 1...)
Affinity DataIC50: 940nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM163433(US9687483, 1 | BA-1049 | US11198680, Compound BA 1...)
Affinity DataIC50: 1.60E+3nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of rat ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM86729(Y-27632 | CAS_146986-50-7 | (R)-(+)-trans-4-(1-ami...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H89 | N-(2-{[(2E)-3-(4-bromophenyl)...)
Affinity DataKi:  270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM14027(AT877 | CHEMBL38380 | 5-(1,4-diazepan-1-ylsulfonyl...)
Affinity DataKi:  330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Rat)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM86727(1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl...)
Affinity DataKi:  450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed