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Report error Found 104 for UniProtKB: Q62205
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to mouse Nav1.7 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  14nMAssay Description:Binding affinity to mouse Nav1.7 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50169425(US9481677, 44 | CHEMBL3341983)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Nav1.7 channel in mouse CAD cells by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
LigandPNGBDBM50257179(CHEMBL2325622)
Affinity DataIC50: 0.550nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of mouse DRG neuron Nav1.7 at -70 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mouse Nav1.7 at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons held at voltage yielding 20% inactivation and depolarized to -10 mV for 40 ms every 10 s by whole-c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of mouse Nav1.7 at -70 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM268527(US9550775, 106 | N-(6-cyclopropyl-7-((3,5-dichloro...)
Affinity DataIC50: 5nMAssay Description:Inhibition of inactivated state of mouse NaV1.7 assessed as decrease in sodium current amplitude at -60 mV holding potential after 20 mins by Qube384...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465061(CHEMBL4290933 | US10550080, Example 47)
Affinity DataIC50: 5nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450581(CHEMBL4159169)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of Nav1.7 in C57/BL6 mouse DRG neurons assessed as reduction in TTX sensitive sodium channel-mediated currents by whole cell manual patch ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450581(CHEMBL4159169)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells after 10 mins by patchxpress-based electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50237517(CHEMBL4078268 | US10836758, Example 20)
Affinity DataIC50: 6nMAssay Description:Inhibition of Nav1.7 in C57BL/6 mouse DRG neurons assessed as reduction in native TTX-S current amplitude by manual patch clamp electrophysiology ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Affinity DataIC50: 7nMAssay Description:Inhibition of inactivated state of mouse NaV1.7 assessed as decrease in sodium current amplitude at -60 mV holding potential after 20 mins by Qube384...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50237517(CHEMBL4078268 | US10836758, Example 20)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -70 mV holding potential measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50269118(CHEMBL4100413)
Affinity DataIC50: 8nMAssay Description:Inhibition of slow inactivated mouse NaV1.7 expressed in HEK293 cells at -20 mV holding potential after 5 mins by IonWorks electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse Nav1.7 in inactivated condition by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50450593(CHEMBL4164272)
Affinity DataIC50: 9nMAssay Description:Inhibition of Nav1.7 in C57/BL6 mouse DRG neurons assessed as reduction in TTX sensitive sodium channel-mediated currents by whole cell manual patch ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM429526(3-(5-Chloro-6-isobutoxypyridin-3-yl)-N-(cyclopropy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242510(CHEMBL4095146)
Affinity DataIC50: 11nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465062(CHEMBL4279180 | US10550080, Example 2)
Affinity DataIC50: 11nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465060(CHEMBL4276864 | US10550080, Example 49)
Affinity DataIC50: 12nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465058(CHEMBL4280298 | US10550080, Example 39)
Affinity DataIC50: 12nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM429527(5-Fluoro-3-(6-isobutoxypyridin-3-yl)-1-methyl-N-(m...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 15nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse Nav1.7 by 5-Hz use-dependent voltage protocol based automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240282(CHEMBL4090731)
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse Nav1.7 alpha expressed in HEK293 cells incubated for 5 mins measured after depolarization to 7 mV for 8s followed by 20ms pulse w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM444926(6-((2,4'-difluoro-5-methoxy-3'-(trifluoromethoxy)-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse Nav1.7 by PatchXpress assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse Nav1.7 at voltage yielding 20 to 50% channel inactivation by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50077464(CHEMBL3416893)
Affinity DataIC50: 23nMAssay Description:Inhibition of NaV1.7 in C57BL/6 mouse DRG neurons at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465063(CHEMBL4287506 | US10550080, Example 45)
Affinity DataIC50: 24nMAssay Description:Inhibition of Nav1.7 in mouse DRG neurons at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50465061(CHEMBL4290933 | US10550080, Example 47)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM217696(US9212182, 672)
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells measured after 3 to 5 mins by patchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50237528(CHEMBL4064193)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant mouse Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current at -70 mV holding potential measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242509(CHEMBL4068937)
Affinity DataIC50: 30nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7alpha incubated for 5 mins measured at 10 secs interval by PatchXpress automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2019
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50545569(CHEMBL4637997)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Mouse)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM371590(US10239869, Example 16 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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