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Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataEC50:  198nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561206(CHEMBL4764985)
Affinity DataEC50:  14nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561238(CHEMBL4752114 | US11325938, Ex 63)
Affinity DataEC50:  41nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561236(CHEMBL4786598 | US11325938, Ex 86)
Affinity DataEC50:  46nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546288(CHEMBL4743437)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of CD73 in mouse CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50527134(CHEMBL4471306 | US20230295213, Compound a)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of CD73 in mouse CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546280(CHEMBL4761506)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of CD73 in mouse CD8-positive T cells using AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CD73 in mouse plasma incubated for 5 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant mouse CD73 (29 to 549 residues) expressed in CHO cells incubated for 1 hr by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: 3nMAssay Description:Inhibition of soluble mouse CD73 incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM435848(US10570167, Cpd. # 174 | US11034715, Cpd. # 174 | ...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant mouse CD73 (29 to 549 residues) expressed in CHO cells incubated for 1 hr by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561221(CHEMBL4745473 | US11377469, Example 95)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse CD73 expressed in CHO cells incubated for 60 mins before addition of AMP and further incubated for 60 mins by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM4078(Elagic Acid | CHEMBL6246 | 6,7,13,14-tetrahydroxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM223080((E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dih...)
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50626492(CHEMBL3211645)
Affinity DataIC50: 210nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50626490(CHEMBL5410323)
Affinity DataIC50: 230nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50626491(CHEMBL3192470)
Affinity DataIC50: 680nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50626478(CHEMBL5404987)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18136(alpha, beta-methyleneadenosine 5 -diphosphate | ci...)
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18136(alpha, beta-methyleneadenosine 5 -diphosphate | ci...)
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM192657(N’-(4-methoxyphenylmethylene)benzohydrazide (...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of mouse Ecto-5'-nucleotidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599943(CHEMBL5177276)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599939(CHEMBL5185215)
Affinity DataIC50: 3.36E+4nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23207((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-5-(hydroxymet...)
Affinity DataIC50: 5.03E+4nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599941(CHEMBL5190085)
Affinity DataIC50: 5.90E+4nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23208(cid_64971 | CHEMBL269277 | (1R,2R,5S,8R,9R,10R,13R...)
Affinity DataIC50: 6.88E+4nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599938(CHEMBL5170776)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599945(CHEMBL5170520)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599944(CHEMBL5187845)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599942(CHEMBL5207600)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599940(CHEMBL5207447)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599937(CHEMBL5177221)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50599936(CHEMBL5191234)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241052(1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-bet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed