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Report error Found 471 of affinity data for UniProtKB/TrEMBL: Q5JRX3
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449404(CHEMBL3127263)
Affinity DataEC50:  57nMAssay Description:Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449405(CHEMBL3127264)
Affinity DataEC50:  152nMAssay Description:Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449404(CHEMBL3127263)
Affinity DataEC50:  601nMAssay Description:Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449405(CHEMBL3127264)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449404(CHEMBL3127263)
Affinity DataEC50:  402nMAssay Description:Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50449405(CHEMBL3127264)
Affinity DataEC50:  713nMAssay Description:Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700117(US20240335569, Compound 3BP-3208)
Affinity DataIC50: 0.631nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700115(US20240335569, Compound 3BP-3205)
Affinity DataIC50: 1nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700137(US20240335569, Compound 3BP-3632)
Affinity DataIC50: 1.26nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
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TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700138(US20240335569, Compound 3BP-3707)
Affinity DataIC50: 1.26nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700154(US20240335569, Compound 3BP-4694)
Affinity DataIC50: 2nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700155(US20240335569, Compound 3BP-4808)
Affinity DataIC50: 2.51nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700151(US20240335569, Compound 3BP-4663)
Affinity DataIC50: 3.98nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622271(US20230312550, Reference Compound B | (R)-N-(2-(4-...)
Affinity DataIC50: 5.20nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622271(US20230312550, Reference Compound B | (R)-N-(2-(4-...)
Affinity DataIC50: 5.20nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700131(US20240335569, Compound 3BP-3581)
Affinity DataIC50: 6.31nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
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TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700132(US20240335569, Compound 3BP-3582)
Affinity DataIC50: 6.31nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700150(US20240335569, Compound 3BP-4201)
Affinity DataIC50: 6.31nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700153(US20240335569, Compound 3BP-4665)
Affinity DataIC50: 6.31nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622272(US20230312550, Reference Compound C | (R)-N-(2-(4-...)
Affinity DataIC50: 7.10nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622272(US20230312550, Reference Compound C | (R)-N-(2-(4-...)
Affinity DataIC50: 7.10nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM682279(US20240207292, Compound 6522L)
Affinity DataIC50: 7.60nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM706120(JHU1220471 | US20240382629, Example 5)
Affinity DataIC50: 11.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/11/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700158(US20240335569, Compound 3BP-4811)
Affinity DataIC50: 12.6nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514515(US11096924, DASH-inhibitors 3102 C | US11583516, C...)
Affinity DataIC50: 15nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700114(US20240335569, Compound 3BP-3134)
Affinity DataIC50: 15.8nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700152(US20240335569, Compound 3BP-4664)
Affinity DataIC50: 15.8nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700156(US20240335569, Compound 3BP-4809)
Affinity DataIC50: 15.8nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514521(US11096924, DASH-inhibitors 4268 | US11583516, Cmp...)
Affinity DataIC50: 23nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622160(US20230312550, Example 120)
Affinity DataIC50: 25nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700116(US20240335569, Compound 3BP-3206)
Affinity DataIC50: 25.1nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622099(US20230312550, Example 59)
Affinity DataIC50: 30nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514516(US11096924, DASH-inhibitors 4175 CH | US11583516, ...)
Affinity DataIC50: 34nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM609771(US11707539, Compound 6487LU | US20240207292, Compo...)
Affinity DataIC50: 34nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622227(US20230312550, Example 187)
Affinity DataIC50: 38nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514514(US11096924, DASH-inhibitors (formerly 3102 A 2C) |...)
Affinity DataIC50: 42nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM706121(JHU1220466 | US20240382629, Example 6)
Affinity DataIC50: 47nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/11/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM702984(US20240366807, Formula I.6)
Affinity DataIC50: 48nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50434166(CHEMBL2385270 | US9346814, Cmpd No 6 Example 9 | U...)
Affinity DataIC50: 48nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514532(US11096924, DASH-inhibitors 3102 A | US11583516, C...)
Affinity DataIC50: 49nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM609765(US11707539, Compound 4536 | US20240207292, Compoun...)
Affinity DataIC50: 50nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM700157(US20240335569, Compound 3BP-4810)
Affinity DataIC50: 50.1nMAssay Description:PREP activity was measured with recombinant human PREP (R&D systems, #4308-SE). The PREP activity assay was performed using the FACS buffer (PBS incl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM702984(US20240366807, Formula I.6)
Affinity DataIC50: 53nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514530(US11096924, DASH-inhibitors 4949 | US11583516, Cmp...)
Affinity DataIC50: 58nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM682244(US20240207292, Compound 2054 | Val-boroPro)
Affinity DataIC50: 58nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM609787(US11707539, Compound 6958LU | US20240207292, Compo...)
Affinity DataIC50: 60nMAssay Description:Enzymatic activity of DPPIV, DPP8, DPP9, FAP, and PREP was measured at 25° C. on a Molecular Devices M2e multidetection microtiter plate reader, moni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM514520(US11096924, DASH-inhibitors 4175 CP | US11583516, ...)
Affinity DataIC50: 68nMAssay Description:Materials: Enzymes Recombinant human DPPIV (R&D Systems, Cat. No. 1180-SE). Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527). Recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622159(US20230312550, Example 119)
Affinity DataIC50: 76nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM622236(US20230312550, Example 196)
Affinity DataIC50: 84nMAssay Description:Table 3: Compounds were tested in a biochemical inhibition assay using Prolyl endopeptidase, Prolyl Oligopeptidase (hPREP) enzyme at 0.6 nM FAC (R&D ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
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TargetPresequence protease, mitochondrial(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM706124(JHU1220502 | US20240382629, Example 9)
Affinity DataIC50: 84.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/11/2025
Entry Details
Go to US Patent

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