Compile Data Set for Download or QSAR
Report error Found 52 for UniProtKB: Q16204
LigandPNGBDBM716172(US12209085, Example 215)
Affinity DataIC50: 0.160nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM716173(US12209085, Example 194)
Affinity DataIC50: 0.260nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.340nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50601766(CHEMBL5171764)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM625352(US20230322769, Compound 65)
Affinity DataIC50: 0.520nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM716174(US12209085, Example 214)
Affinity DataIC50: 0.600nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
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LigandPNGBDBM716171(US12209085, Example 4)
Affinity DataIC50: 0.600nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50514844(CHEMBL4473213)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM716170(US12209085, Example 3)
Affinity DataIC50: 0.800nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

LigandPNGBDBM716112(US12209085, Example 1)
Affinity DataIC50: 0.870nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

LigandPNGBDBM625351(US20230322769, Compound 70 | US20230322769, Compou...)
Affinity DataIC50: 1.02nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 1.13nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 2.07nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625338(US20230322769, Compound 20)
Affinity DataIC50: 2.14nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625346(US20230322769, Compound 51)
Affinity DataIC50: 2.15nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM625350(US20230322769, Compound 68 | US20230322769, Compou...)
Affinity DataIC50: 2.54nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625337(US20230322769, Compound 17)
Affinity DataIC50: 2.61nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625367(US20230322769, Compound 94 | US20230322769, Compou...)
Affinity DataIC50: 3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625369(US20230322769, Compound 89)
Affinity DataIC50: 3.04nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625342(US20230322769, Compound 32)
Affinity DataIC50: 3.13nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM716175(US12209085, Example 268)
Affinity DataIC50: 3.16nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent

LigandPNGBDBM625335(US20230322769, Compound 16)
Affinity DataIC50: 3.65nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 4.44nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

LigandPNGBDBM625358(US20230322769, Compound 78)
Affinity DataIC50: 4.60nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538514(CHEMBL4644274)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50556136(CHEMBL4790634)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM625350(US20230322769, Compound 68 | US20230322769, Compou...)
Affinity DataIC50: 6.01nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538517(CHEMBL4639022)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM625347(US20230322769, Compound 55)
Affinity DataIC50: 7.45nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
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LigandPNGBDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 8.07nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

LigandPNGBDBM625351(US20230322769, Compound 70 | US20230322769, Compou...)
Affinity DataIC50: 12nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538516(CHEMBL4643578)
Affinity DataIC50: 15nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538515(CHEMBL4636056)
Affinity DataIC50: 16nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM625340(US20230322769, Compound 17-a)
Affinity DataIC50: 17.2nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50595124(VANDETANIB | CHEBI:49960 | Vandetanib | GNF-PF-218...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM625351(US20230322769, Compound 70 | US20230322769, Compou...)
Affinity DataIC50: 30.7nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50021574(CHEBI:72317 | CABOZANTINIB | BMS-907351 | Cometriq...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50575351(CHEMBL4874648)
Affinity DataIC50: 35nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50575350(CHEMBL4877264)
Affinity DataIC50: 46nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50575353(CHEMBL4859681)
Affinity DataIC50: 51nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538512(CHEMBL4638840)
Affinity DataIC50: 56nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
LigandPNGBDBM625341(US20230322769, Compound 21)
Affinity DataIC50: 60.5nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

LigandPNGBDBM625343(US20230322769, Compound 34)
Affinity DataIC50: 71.6nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538507(CHEMBL4640601)
Affinity DataIC50: 95nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50575352(CHEMBL4857808)
Affinity DataIC50: 110nMAssay Description:Inhibition of CCDC6-RET fusion protein (unknown origin) expressed in human LC-2-ad cells assessed as reduction in cell proliferation incubated for 6 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50538510(CHEMBL4640989)
Affinity DataIC50: 160nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
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