Compile Data Set for Download or QSAR
Report error Found 27 of affinity data for UniProtKB/TrEMBL: Q15047
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521991(CHEMBL4589361)
Affinity DataKd:  7.70E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50512971(CHEMBL4471746)
Affinity DataKd:  4.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641849(CHEMBL5572139)
Affinity DataKd:  232nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641848(CHEMBL5564879)
Affinity DataKd:  3.26E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50512975(CHEMBL4471748)
Affinity DataKd:  1.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50512967(CHEMBL4449143)
Affinity DataKd:  210nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521989(CHEMBL4453131)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to N-terminal His6-tagged human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by IT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521992(CHEMBL4455427)
Affinity DataKd:  2.50E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521990(CHEMBL4576037)
Affinity DataKd:  3.50E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521990(CHEMBL4576037)
Affinity DataKd:  3.50E+6nMAssay Description:Binding affinity to N-terminal His6-tagged human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by IT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521989(CHEMBL4453131)
Affinity DataKd:  4.00E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521988(CHEMBL4456448)
Affinity DataKd:  1.27E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521987(CHEMBL4542222)
Affinity DataKd:  2.70E+6nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50521986(CHEMBL4451286)
Affinity DataKd:  1.00E+7nMAssay Description:Binding affinity to N-terminally biotinylated human SETDB1 Tudor domain (197 to 403 residues) expressed in Escherichia coli BL21(DE3)-pRARE2 cells by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataKd:  80nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-rib...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of SETDB1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641850(CHEMBL5572230)
Affinity DataIC50: 6.50E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 1.00E+5nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50630063(CHEMBL5439383)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from SETDB1 tandem tudor domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50630038(CHEMBL5403027)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of Biotin-p53K381acK382me2 from SETDB1 tandem tudor domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50063670(CHEMBL3397332)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SETDB1 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SETDB1 (unknown origin) assessed as incorporation of tritium-labeled methyl group to lysine or arginine residues of peptide substrate b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataIC50: 7.50E+5nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataIC50: 9.30E+5nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)