Compile Data Set for Download or QSAR
Report error Found 330 of affinity data for UniProtKB/TrEMBL: Q14831
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50393322(CHEMBL2152119)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at human mGlu 7 expressed in HEK293 cells by Ca+2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50004881(Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG) | (...)
Affinity DataEC50:  4.80E+4nMAssay Description:Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR7bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50004881(Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG) | (...)
Affinity DataEC50:  4.80E+4nMAssay Description:Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR7bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50074749(LY379268 | (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50074750(LY-389795 | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50353291(CHEMBL1830711)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50353290(CHEMBL1830707)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50064463(CHEMBL3401177)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50064444(CHEMBL3401195)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50132507(CHEMBL3633943)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu7 receptor (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50089518((1R,2R)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at mGlu7 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50089516((1R,2S)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Affinity DataEC50: >3.00E+6nMAssay Description:Agonist activity at mGlu7 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50217030((1S,2S)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  6.25E+5nMAssay Description:Agonist activity at mGlu7 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50217031((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...)
Affinity DataEC50:  6.02E+5nMAssay Description:Agonist activity at mGlu7 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu7 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50134443(CHEMBL3746457)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50426287(CHEMBL2312685)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50426288(CHEMBL2312684)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50426290(CHEMBL2312682)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50252047((2S,4S)-4-aminobutane-1,2,4-tricarboxylic acid | (...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  1.18E+3nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50426285(CHEMBL2312403)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50426289(CHEMBL2312683)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50252049((2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid | (...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human mGlu7 receptor expressed in HEK293 assessed as inhibition of forskolin stimulated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50353292(CHEMBL1830698)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu7 receptor assessed as potentiation of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50: >1.00E+6nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR7 in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50: >5.00E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR7 in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM17660(2-amino-3-(3,5-dioxo[1,2,4]oxadiazolidin-2-yl)prop...)
Affinity DataEC50: >1.00E+6nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR7 in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  2.00E+5nMAssay Description:Concentration for half maximal activation of metabotropic glutamate mGluR7 in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  1.88E+5nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50175073((S)-2-amino-2-((1S,2R)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50175072((S)-2-amino-2-((1R,2S)-2-phosphonocyclopropyl)acet...)
Affinity DataEC50:  7.00E+5nMAssay Description:Activity at human mGluR7 by measuring cAMP formation in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human recombinant mGluR7 expressed in BHK cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50207814((2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine | ...)
Affinity DataEC50:  7.00E+5nMAssay Description:Activity at human recombinant mGluR7 expressed in BHK cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  1.88E+5nMAssay Description:Activity at human recombinant mGluR7 expressed in BHK cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50207811((2S,1'R,2'S,3'R)-2-(2'-phosphono-3'-phenylcyclopro...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human recombinant mGluR7 expressed in BHK cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50207813((2S,1'S,2'R,3'S)-2-(2'-phosphono-3'-phenylcyclopro...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity at human recombinant mGluR7 expressed in BHK cells assessed as cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as increase in Ca2+ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2018
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM49388(7-(benzyloxy)-2,3-dihydro-4H-chromen-4-one | SMR00...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50337525(7-(phenoxymethyl)chroman-4-one | CHEMBL1682820)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50440205(CHEMBL2426621)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50440185(CHEMBL2426616)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells by fluorescent Ca2+ assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50392432(CHEMBL2151817)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50388941(CHEMBL2063423)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation activity at mGlu7 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at recombinant human mGlu7 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as induction of increa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50060137((1R,2S,4s)-4-aminocyclopentane-1,2,4-tricarboxylic...)
Affinity DataEC50:  2.80E+5nMAssay Description:Agonist activity at mGlu7 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50255388(CHEMBL4093492)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at mGlu7 (unknown origin) expressed in HEK293 cells coexpressing chimeric Gq/i protein assessed as [3H]inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2019
Entry Details Article
PubMed
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