Compile Data Set for Download or QSAR
Report error Found 1092 for UniProtKB: Q13639
LigandPNGBDBM29532((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,...)
Affinity DataEC50:  1.00E+4nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29528(ML10302 scaffold, 9{a;y})
Affinity DataAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM29529(ML10302 scaffold, 14)
Affinity DataEC50:  9.00E+3nMAssay Description:EC/IC50 was the effective concentration of agonist inhibiting the formation of A-beta fibrils to 50% of the control value. Three independent measurem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2009
Entry Details Article
PubMed
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  0.900nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.360nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human 5HT4B receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.260nMAssay Description:Agonist activity at human 5HT4E receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.200nMAssay Description:Partial agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398598(CHEMBL2152922)
Affinity DataEC50:  0.470nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398588(CHEMBL2179582)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398590(CHEMBL2179583)
Affinity DataEC50:  0.380nMAssay Description:Agonist activity at human 5HT4A receptor expressed in HEK293 cells assessed as increase in cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50327870((1-Butylpiperidin-4-yl)methyl 7-iodo-8-(methylamin...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327867((1-Butylpiperidin-4-yl)methyl 8-(methylamino)-2,3-...)
Affinity DataEC50:  8.90nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327869((1-Butylpiperidin-4-yl)methyl 7-bromo-8-(methylami...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327872((1-Butylpiperidin-4-yl)methyl 4-Amino-2-methoxyben...)
Affinity DataEC50:  0.178nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327871((1-Butylpiperidin-4-yl)methyl 7-cyano-8-(methylami...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50327858(CHEMBL114112 | SB207710 | 8-Amino-7-iodo-2,3-dihyd...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
LigandPNGBDBM50092543(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Affinity DataKd:  0.700nMAssay Description:,Antagonism of stimulation of 5-hydroxytryptamine receptor on the L-type calcium current (I Ca) in isolated human atrial myocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092543(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Affinity DataEC50:  66nMAssay Description:Concentration required to produce half-maximal response against 5-hydroxytryptamine receptor in the presence of 10 nM compound in isolated human atri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50092543(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Affinity DataEC50:  4.5nMAssay Description:Concentration required to produce half-maximal response against 5-hydroxytryptamine receptor on the L-type calcium current (I Ca) in isolated human a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50079362(CHEMBL3417009 | US9663465, 9)
Affinity DataEC50:  11nMAssay Description:Activity at 5-HT4R (unknown origin) expressed in COS7 cells assessed as increase in sAPPalpha releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/28/2016
Entry Details Article
PubMed
LigandPNGBDBM29525(GR 113808 | [3H] GR 113808 | CHEMBL518682 | 3H-GR1...)
Affinity DataKd:  15.8nMAssay Description:Binding affinity to human 5HT4 receptor expressed in HEK293 cells by saturation binding methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50122878(4-Amino-5-chloro-2,3-dihydro-benzofuran-7-carboxyl...)
Affinity DataEC50:  14nMAssay Description:Compound was tested for 5-hydroxytryptamine 4 binding affinityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  100nMAssay Description:Activity at SER4 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50301927(Norcisapride | CHEMBL1748)
Affinity DataEC50:  290nMAssay Description:Agonist activity at human recombinant 5-HT4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50301928(4-amino-5-chloro-N-((3R,4S)-1-(((1S,2S)-2-hydroxy-...)
Affinity DataEC50:  90nMAssay Description:Agonist activity at human recombinant 5-HT4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50301929(4-amino-5-chloro-N-((3S,4R)-1-(((1S,2S)-2-hydroxy-...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human recombinant 5-HT4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50399616(CHEMBL2181188)
Affinity DataEC50:  251nMAssay Description:Inverse agonist activity at human recombinant 5HT4R expressed in HEK293T cells assessed as Gs activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399620(CHEMBL2181187)
Affinity DataEC50:  79.4nMAssay Description:Inverse agonist activity at human recombinant 5HT4R expressed in HEK293T cells assessed as Gs activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399619(CHEMBL2181189)
Affinity DataEC50:  63.1nMAssay Description:Inverse agonist activity at human recombinant 5HT4R expressed in HEK293T cells assessed as Gs activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50399615(CHEMBL2181171)
Affinity DataEC50:  10nMAssay Description:Inverse agonist activity at human recombinant 5HT4R expressed in HEK293T cells assessed as Gs activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398589(CHEMBL2179588)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398591(CHEMBL2179581)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398592(CHEMBL2179590)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398593(CHEMBL2179587)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398594(CHEMBL2179585)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398595(CHEMBL2179586)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398596(CHEMBL2179589)
Affinity DataEC50:  0.980nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398597(CHEMBL2179584)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398599(CHEMBL2179580)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human 5HT4D receptor expressed in HEK293 cells assessed as cAMP production after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50213015(CHEMBL82360)
Affinity DataEC50:  16nMAssay Description:Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandPNGBDBM50213016(CHEMBL79637)
Affinity DataEC50:  13nMAssay Description:Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandPNGBDBM50213017(CHEMBL80015)
Affinity DataEC50:  40nMAssay Description:Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

LigandPNGBDBM50213018(CHEMBL310451)
Affinity DataEC50:  126nMAssay Description:Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosaeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details

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