Compile Data Set for Download or QSAR
Report error Found 1782 of affinity data for UniProtKB/TrEMBL: Q13255
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50288204((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...)
Affinity DataEC50:  2.10E+5nMAssay Description:Compound was tested for its agonist activity against mGluR1a receptor in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50053589((S)-3-Hydroxyphenylglycine | 3HPG | CHEMBL442347 |...)
Affinity DataEC50:  6.80E+4nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034501((S)-Amino-(3-oxo-2,3-dihydro-isoxazol-5-yl)-acetic...)
Affinity DataEC50:  6.00E+3nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17660(2-amino-3-(3,5-dioxo[1,2,4]oxadiazolidin-2-yl)prop...)
Affinity DataEC50:  200nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50:  2.20E+4nMAssay Description:Effective concentration for half maximal stimulation of PI hydrolysis (mGluR1a)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407827(CHEMBL2115160)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407821(CHEMBL2115151)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407829(CHEMBL2115153)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407822(CHEMBL2114112)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407824(CHEMBL2114115)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407831(CHEMBL2115156)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407818(CHEMBL2114109)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407830(CHEMBL2115157)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407825(CHEMBL2114110)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407823(CHEMBL2114116)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50407820(CHEMBL2115159)
Affinity DataEC50: >3.00E+5nMAssay Description:Concentration required for half-maximal stimulation of PI hydrolysis in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052256(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Affinity DataEC50: >3.00E+5nMAssay Description:The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50052255(3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane...)
Affinity DataEC50: >3.00E+5nMAssay Description:The compound was tested for effect on second messenger formation in BHK cells expressing mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50004863(1S, 3R-ACPD | CHEMBL29726 | 1R,3R-ACPD | 1R,3S-ACP...)
Affinity DataEC50: >3.00E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50060136((1R,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid...)
Affinity DataEC50:  1.27E+5nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50060133(CHEMBL107845 | 1S, 3S-ACPD | 1-Amino-cyclopentane-...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50079183(amino(3,5-dihydroxyphenyl)acetic acid | 3,5-DHPG |...)
Affinity DataEC50:  6.60E+3nMAssay Description:Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50074749(LY379268 | (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50074750(LY-389795 | 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50056272((2S,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of forskolin stimulated cAMP production in RGT cells expressing recombinant human mGluR1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50180145((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Affinity DataEC50: >1.00E+6nMAssay Description:Activity against mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326794((+/-)(1R,2S,3S)-3-[(S)-amino(carboxy)-methyl]-1,10...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50326793((+/-)(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyc...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50138781(2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarb...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50353291(CHEMBL1830711)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50353292(CHEMBL1830698)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064463(CHEMBL3401177)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50064444(CHEMBL3401195)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation at mGluR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132507(CHEMBL3633943)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu1 receptor (unknown origin) relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132710(CHEMBL3634432)
Affinity DataEC50:  144nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132712(CHEMBL3632642)
Affinity DataEC50:  18nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132773(CHEMBL3634431)
Affinity DataEC50:  49nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132774(CHEMBL3634430)
Affinity DataEC50:  46nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132775(CHEMBL3634429)
Affinity DataEC50:  155nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132776(CHEMBL3634428)
Affinity DataEC50:  106nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132777(CHEMBL3634427)
Affinity DataEC50:  530nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132778(CHEMBL3634426)
Affinity DataEC50:  123nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132779(CHEMBL3634425)
Affinity DataEC50:  49nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132780(CHEMBL3634424)
Affinity DataEC50:  49nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132781(CHEMBL3634423)
Affinity DataEC50:  21nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132782(CHEMBL3634422)
Affinity DataEC50:  89nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132783(CHEMBL3634421)
Affinity DataEC50:  35nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132784(CHEMBL3634420)
Affinity DataEC50:  28nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50132785(CHEMBL3634419)
Affinity DataEC50:  26nMAssay Description:Positive allosteric modulation of human mGluR1 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2016
Entry Details Article
PubMed
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