Compile Data Set for Download or QSAR
Report error Found 16 of affinity data for UniProtKB/TrEMBL: Q05320
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataKd:  9.50E+5nMAssay Description:Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50247471(CHEMBL558805)
Affinity DataKd:  1.30E+6nMAssay Description:Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM78577(cid_50088 | N-benzyl-N-[3-(2-methylpropoxy)-2-pyrr...)
Affinity DataKd:  2.90E+5nMAssay Description:Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM58492(2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]...)
Affinity DataKd:  1.60E+4nMAssay Description:Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM22416(PAROXETINE | CHEMBL490 | (3S,4R)-3-[(1,3-benzodiox...)
Affinity DataKd:  6.50E+5nMAssay Description:Binding affinity to Ebola virus Zaire Mayinga-76 recombinant GP protein by SYPRO orange dye-based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50459313(CHEMBL4206744)
Affinity DataEC50:  1.02E+3nMAssay Description:Inhibition of Ebola virus Sudan envelope glycoprotein-mediated cell entry in human HuH7 cells treated with 30 mins pre-treated pseudovirus/compopund ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM77970(CLOMIPRAMINE HYDROCHLORIDE | CHLORIMIPRAMINE | 3-(...)
Affinity DataKd:  1.18E+5nMAssay Description:Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM58492(2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]...)
Affinity DataKd:  1.60E+4nMAssay Description:Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain T42A mutant tagged with 6xHis/foldon trimerization sequence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | Imipramin | IMIPRAMINE HYDROCHLORIDE | ...)
Affinity DataKd:  5.84E+5nMAssay Description:Binding affinity to EBOV Mayinga, Zaire, 1976 envelope glycoprotein extracellular domain H613A mutant tagged with His/foldon trimerization sequence f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM58492(2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]...)
Affinity DataEC50:  63nMAssay Description:Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM58492(2-[4-[(Z)-4-chloro-1,2-diphenylbut-1-enyl]phenoxy]...)
Affinity DataEC50:  63nMAssay Description:Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM521546(US11149049, No. C1)
Affinity DataEC50:  800nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM521548(Isopropyl ((((2S,3 S,4R,5R)-5-(4-aminopyrrolo[2, l...)
Affinity DataEC50:  2.50E+3nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM521549(Diisopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1...)
Affinity DataEC50:  200nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM521550(Neopentyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f...)
Affinity DataEC50:  500nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetEnvelope glycoprotein(ZEBOV)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM521551(2-Ethylbutyl ((((2S,3S,4R,5R)-5-(4-aminopyrrolo[2,...)
Affinity DataEC50:  250nMAssay Description:HEp-2 cells were plated in 96-well plates at the density of 40,000 cells/well. On the next day, modified vaccinia virus Ankara-T7 (MVA-T7) at the mul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent