Compile Data Set for Download or QSAR
Report error Found 50 of affinity data for UniProtKB/TrEMBL: Q04750
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249683(2,10-Dihydroxy-6-[(4-cyanobenzyl)amino]-13-(beta-D...)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249691(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  160nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249669(6-[(2-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  180nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249675(2,10-Dihydroxy-6-[(pyrazin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  210nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249687(2,10-Dihydroxy-6-{[3-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  220nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249692(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  400nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249674(2,10-Dihydroxy-6-[(pyridin-4-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  420nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249670(6-[(3-Furylmethyl)amino]-2,10-dihydroxy-13-(beta-D...)
Affinity DataEC50:  470nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249685(2,10-Dihydroxy-6-{[4-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  600nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249672(2,10-Dihydroxy-6-[(pyridin-2-ylmethyl)amino]-13-(b...)
Affinity DataEC50:  800nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249696(2,10-Dihydroxy-6-({[3-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  130nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249676(2,10-Dihydroxy-6-[(quinolin-2-ylmethyl)amino]-13-(...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249681(2,10-Dihydroxy-6-[(4-nitrolbenzyl)amino]-13-(beta-...)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249671(2,10-Dihydroxy-6-[(1H-pyrrol-2-ylmethyl)amino]-13-...)
Affinity DataEC50:  6.50E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249678(2,10-Dihydroxy-6-[(quinolin-4-ylmethyl)amino]-13-(...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249682(2,10-Dihydroxy-6-[(4-bromobenzyl)amino]-13-(beta-D...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249693(2,10-Dihydroxy-6-({[4-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249673(2,10-Dihydroxy-6-[(pyridin-3-ylmethyl)amino]-13-(b...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249677(2,10-Dihydroxy-6-[(quinolin-3-ylmethyl)amino]-13-(...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249695(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  130nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249679(edotecarin | CHEMBL447069)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249694(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-3-yl]...)
Affinity DataEC50:  90nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249668(6-(Benzylamino)-2,10-dihydroxy-13-(beta-D-glucopyr...)
Affinity DataEC50:  80nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249689(2,10-Dihydroxy-6-({[6-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  73nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249688(2,10-Dihydroxy-6-{[2-(hydroxymethyl)benzyl]amino}-...)
Affinity DataEC50:  24nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249686(2,10-Dihydroxy-6-[(3-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  23nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249697(2,10-Dihydroxy-6-({[2-(hydroxymethyl)pyridin-4-yl]...)
Affinity DataEC50:  100nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249680(2,10-Dihydroxy-6-[(4-methylbenzyl)amino]-13-(beta-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249684(2,10-Dihydroxy-6-[(4-hydroxybenzyl)amino]-13-(beta...)
Affinity DataEC50:  120nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50249690(2,10-Dihydroxy-6-({[5-(hydroxymethyl)pyridin-2-yl]...)
Affinity DataEC50:  120nMAssay Description:Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50242319(4-hydroxysaprothoquinone | CHEMBL453303)
Affinity DataIC50: 800nMAssay Description:Inhibition of topoisomerase 1 extracted from mouse EAC cells assessed as inhibition of Escherichia coli pBR322 relaxationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50092821(CHEMBL837 | 4,11-diethyl-4,9-dihydroxy-(4S)-3,4,12...)
Affinity DataIC50: 4.00E+3nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099251(9,16-diethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahyd...)
Affinity DataIC50: 5.00E+3nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099248(1,9-diethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahydr...)
Affinity DataIC50: 1.20E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099250(2-[9-ethyl-9-hydroxy-10,13-dioxo-(9S)-2,3,9,10,13,...)
Affinity DataIC50: 1.60E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50008935(CHEMBL84 | 10-Dimethylaminomethyl-4-ethyl-4,9-dihy...)
Affinity DataIC50: 2.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099246(9-ethyl-9-hydroxy-1-methyl-(9S)-2,3,9,10,13,15-hex...)
Affinity DataIC50: 2.10E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataIC50: 4.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099244(9-ethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahydro-1H...)
Affinity DataIC50: 4.10E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50081429((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...)
Affinity DataIC50: 6.30E+4nMAssay Description:In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50081428((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...)
Affinity DataIC50: 1.02E+5nMAssay Description:In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099245(1-(2-aminoethyl)-9-ethyl-9-hydroxy-(9S)-2,3,9,10,1...)
Affinity DataIC50: 1.33E+5nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50081427((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...)
Affinity DataIC50: 1.72E+5nMAssay Description:In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50081431(7,16-dihydroxy-5,14-dimethyl-(1S,13S,16R)-2-oxa-14...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50081426((4R,4aS)-4,8-Dihydroxy-6-methyl-9-oxo-4,9-dihydro-...)
Affinity DataIC50: 3.00E+5nMAssay Description:In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50164888(6-Hydroxy-3-[1-(4-hydroxy-phenyl)-meth-(E)-ylidene...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50099253(9,16-diethyl-9-hydroxy-1-methyl-(9S)-2,3,9,10,13,1...)
Affinity DataIC50: 1.60E+6nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed