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TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50092310(US9675697, Cpd. No. 23 | CHEMBL3581661)
Affinity DataKd:  9.50E+3nMAssay Description:Binding affinity to biotinylated MLL1 (1566 to 1784 amino acid residues) (unknown origin) expressed in Rosetta2 cells by bio-layer interferometry met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50282115(CHEMBL4165111)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to 15N-labeled GST-tagged MLL1 PHD3 finger domain (1565 to 1627 residues) (unknown origin) expressed in Escherichia coli Rosetta2 BL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM553008(US11319299, Example 58 | N-(5-(2- morpholinopyrimi...)
Affinity DataKd:  3.5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM553032(US11319299, Example 82 | N-[4-chloro-5-(2- morphol...)
Affinity DataKd:  10nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM553011(US11319299, Example 61 | US11319299, Example Tabl...)
Affinity DataKd:  26nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
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TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM553009(US11319299, Example 59 | N-[5-(2-morpholin-4- ylpy...)
Affinity DataKd: >1.00E+4nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM553005(US11319299, Example 55 | US11319299, Example Tabl...)
Affinity DataKd: >200nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM552953(US11319299, Example 8 | US11319299, Example Table...)
Affinity DataKd: <0.5nMAssay Description:Exemplary compounds of the application were dissolved in 100% DMSO at 10 mM, assayed fresh, and then stored at −20° C. for repeat studies and o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481596(CHEMBL5277870)
Affinity DataKd: >1.00E+5nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481597(CHEMBL5281856)
Affinity DataKd: >1.50E+4nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481598(CHEMBL5272698)
Affinity DataKd:  8.30E+3nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481599(CHEMBL5283185)
Affinity DataKd:  7.30E+3nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481600(CHEMBL5283334)
Affinity DataKd:  6.00E+3nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481601(CHEMBL5274392)
Affinity DataKd:  3.30E+3nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50481602(CHEMBL5277647)
Affinity DataKd:  1.00E+3nMAssay Description:Competitive binding affinity to full length wild type MLL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725748(US20250074910, Example 45)
Affinity DataIC50: 2.5nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725770(US20250074910, Example 59-1)
Affinity DataIC50: 2.5nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617530(US20230286925, Compound HYBI_087)
Affinity DataIC50: 2.60nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725736(US20250074910, Example 38-2)
Affinity DataIC50: 2.80nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725767(US20250074910, Example 58-1)
Affinity DataIC50: 2.90nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470578(US10815241, Example 3 | US11369605, Example 3)
Affinity DataIC50: 3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470581(5-Fluoro-2-[(4-{7-[(1S,3S,4R)-5-methylidene-2-azab...)
Affinity DataIC50: 3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470582(US10815241, Example 7 | US11369605, Example 7)
Affinity DataIC50: 3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470585(US10815241, Example 10 | US11369605, Example 10)
Affinity DataIC50: 3nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617532(US20230286925, Compound HYBI_110)
Affinity DataIC50: 3nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617525(US20230286925, Compound HYBI_083)
Affinity DataIC50: 3.08nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725718(US20250074910, Example 19)
Affinity DataIC50: 3.30nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725734(US20250074910, Example 37-2)
Affinity DataIC50: 3.30nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725731(US20250074910, Example 35)
Affinity DataIC50: 3.60nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617531(US20230286925, Compound HYBI_101)
Affinity DataIC50: 3.65nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617528(US20230286925, Compound HYBI_085)
Affinity DataIC50: 3.86nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617529(US20230286925, Compound HYBI_086)
Affinity DataIC50: 3.99nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470580(US10815241, Example 5 | US11369605, Example 5)
Affinity DataIC50: 4.10nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725732(US20250074910, Example 36)
Affinity DataIC50: 4.40nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617526(US20230286925, Compound HYBI_084)
Affinity DataIC50: 4.72nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617524(US20230286925, Compound HYBI_082)
Affinity DataIC50: 4.91nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725716(US20250074910, Example 17)
Affinity DataIC50: 5nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
Huyabio International

US Patent
LigandPNGBDBM617511(US20230286925, Compound HYBI_028)
Affinity DataIC50: 5.24nMAssay Description:WDR5 TR-FRET Assay Procedure: Stock compounds were transferred to the assay plate by Echo Liquid Handler. Reactions were performed in the assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM558847(US11369605, Example 1 | 2-[(4-{7-[(1S,3S,4R,6S)-6-...)
Affinity DataIC50: 5.30nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725768(US20250074910, Example 58-1a)
Affinity DataIC50: 5.40nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725769(US20250074910, Example 58-1b)
Affinity DataIC50: 5.90nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725719(US20250074910, Example 20)
Affinity DataIC50: 6nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM554135(US11325921, Example 22)
Affinity DataIC50: 6.20nMAssay Description:Test for Evaluating the Inbinition of the Menin-MLL BindingMenin1-615 wherein 6× His tag and HA tag are inserted in the N-terminus, and myc tag is in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470584(US10815241, Example 9 | US11369605, Example 9)
Affinity DataIC50: 6.20nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725717(US20250074910, Example 18)
Affinity DataIC50: 6.30nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM725730(US20250074910, Example 34)
Affinity DataIC50: 6.40nMAssay Description:The inhibition of Menin/MLL-4-43 peptide interaction by small molecule inhibitors was quantitatively detected by fluorescence polarization competitio...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/9/2025
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase 2A/Menin(Human)
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM470586(US10815241, Example 11 | US11369605, Example 11)
Affinity DataIC50: 7nMAssay Description:Menin1-615 wherein 6×His tag and HA tag are inserted in the N-terminus, and myc tag is inserted in the C-terminus (hereinafter, referred to as His-Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent

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