Compile Data Set for Download or QSAR
Report error Found 3876 of affinity data for UniProtKB/TrEMBL: Q02127
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550723(CHEMBL4740037)
Affinity DataEC50:  4.40E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550724(CHEMBL4750208)
Affinity DataEC50:  2.70E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550725(CHEMBL4790954)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550726(CHEMBL3128254)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550723(CHEMBL4740037)
Affinity DataEC50:  4.47E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550724(CHEMBL4750208)
Affinity DataEC50:  2.69E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550727(CHEMBL3128253)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataEC50:  8.90E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataEC50:  2.80E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50069959(Sodium; 6-fluoro-2-(2'-fluoro-biphenyl-4-yl)-3-met...)
Affinity DataEC50:  55nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)
Affinity DataEC50:  2.75E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataEC50:  8.91E+3nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550728(CHEMBL4748412)
Affinity DataEC50:  5.25E+4nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550729(CHEMBL4753543)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550730(CHEMBL4777624)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550731(CHEMBL4745158)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550732(CHEMBL4755999)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550733(CHEMBL4795021)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550734(CHEMBL4789182)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550735(CHEMBL4748394)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550736(CHEMBL4741980)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50550737(CHEMBL4743368)
Affinity DataEC50: <1.58E+5nMAssay Description:Inhibition of DHODH in human HEK-293 cells transfected with ISRE-luciferase reporter gene assessed as increase in IFN-alpha mediated cellular respons...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50598913(CHEMBL5193591)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to His fused human DHODH expressed in Escherichia coli by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50598923(CHEMBL5193821)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to His fused human DHODH expressed in Escherichia coli by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50622955(CHEMBL5398316)
Affinity DataKd:  1.30E+5nMAssay Description:Inhibition of human DHODH assessed as dissociation constant by surface plasmon resonance (SPR) based spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50612557(CHEMBL5274468)
Affinity DataEC50:  3nMAssay Description:Inhibition of DHODH in human HeLa cells assessed as reduction in hypoxia-induced VEGF expression incubated for 48 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50612558(CHEMBL5289415)
Affinity DataEC50:  680nMAssay Description:Inhibition of DHODH in human HeLa cells assessed as reduction in hypoxia-induced VEGF expression incubated for 48 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50612559(CHEMBL5279134)
Affinity DataEC50:  13nMAssay Description:Inhibition of DHODH in human HeLa cells assessed as reduction in hypoxia-induced VEGF expression incubated for 48 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50612560(CHEMBL5275789)
Affinity DataEC50:  1nMAssay Description:Inhibition of DHODH in human HeLa cells assessed as reduction in hypoxia-induced VEGF expression incubated for 48 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataKd:  2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM470573(methyl 1-(4-[(2,6-difluorophenyl)carbamoyl]-2-fluo...)
Affinity DataIC50: 0nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50554026(CHEMBL4744558)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50549950(CHEMBL4751541 | US11505536, Example 66)
Affinity DataIC50: 0.169nMAssay Description:Inhibition of human DHODH (30 to 390 residues) expressed in Escherichia coli using dihydroorotate as substrate and CoQ10 as co-substrate by DCIP dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50549950(CHEMBL4751541 | US11505536, Example 66)
Affinity DataIC50: 0.169nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675277(US20240158414, Example 33)
Affinity DataIC50: 0.170nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675283(US20240158414, Example 39)
Affinity DataIC50: 0.170nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675295(US20240158414, Example 51)
Affinity DataIC50: 0.170nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675344(US20240158414, Example 101)
Affinity DataIC50: 0.170nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581628(CHEMBL5077700 | US20240158414, Example 175)
Affinity DataIC50: 0.179nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581628(CHEMBL5077700 | US20240158414, Example 175)
Affinity DataIC50: 0.179nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM530430(6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...)
Affinity DataIC50: 0.180nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
WIPO WO2022070068

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM530430(6-(6-Amino-5-methylpyridin-2-yl)-7-fluoro-4-isopro...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human DHODH using dihydroorotate and CoQ6 as substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675322(US20240158414, Example 79)
Affinity DataIC50: 0.181nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581627(CHEMBL5085549 | US20240158414, Example 130)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581627(CHEMBL5085549 | US20240158414, Example 130)
Affinity DataIC50: 0.190nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675343(US20240158414, Example 100)
Affinity DataIC50: 0.191nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581625(CHEMBL5075013)
Affinity DataIC50: 0.192nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675340(US20240158414, Example 97)
Affinity DataIC50: 0.192nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM675386(US20240158414, Example 145)
Affinity DataIC50: 0.193nMAssay Description:DHODH Enzymatic Assay: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Paris Descartes University

Curated by ChEMBL
LigandPNGBDBM50581624(CHEMBL5083643 | US20240158414, Example 69)
Affinity DataIC50: 0.195nMAssay Description:Inhibition of human DHODH using dihydroorotate as substrate and CoQ6 as co-substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
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