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TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50234661(CHEMBL1619630 | CHEBI:76227)
Affinity DataEC50:  2.12E+5nMAssay Description:Inhibition of Rac1 in human HeLa cells pretreated for 1 hr followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50533571(CHEMBL1618254 | US11459295, Compound R-Naproxen (1...)
Affinity DataEC50:  574nMAssay Description:Inhibition of Rac1 in human HeLa cells pretreated for 2 hrs followed by EGF stimulation for 2 mins by flow cytometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  50nMAssay Description:Binding affinity to Rac1b (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618632(CHEMBL1186585)
Affinity DataKd:  40nMAssay Description:Binding affinity to Rac1 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constant by fluorescence anisotropy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391240(CHEMBL496240 | CHEBI:76228)
Affinity DataEC50:  574nMAssay Description:Inhibition of Rac1 in human HeLa cells by Flow cytometric G-trap effector binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391239(CHEMBL1404260)
Affinity DataEC50:  2.24E+4nMAssay Description:Inhibition of Rac1 in human HPAF-II cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391238(CHEMBL5277596)
Affinity DataEC50:  8.30E+3nMAssay Description:Inhibition of Rac1 in human HPAF-II cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391237(CHEMBL5290216)
Affinity DataIC50: 100nMAssay Description:Inhibition of Rac1 GTPase in human breast cancer cell line treated for 24 hrs by western blot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50234661(CHEMBL1619630 | CHEBI:76227)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2019
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells incubated for 24 hrs by pull-down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Vav2 binding to Rac1 G15A mutant in human MDA-MB-231 cells after 1 hr by pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50618633(CHEMBL5436670)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of GTP-tagged recombinant Rac1 (unknown origin) PAK binding domain expressed in HEK293T cells by pull- down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandPNGBDBM85511(Toradol | KETOROLAC | CAS_74103-07-4 | Ketorolac t...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of RAC1/CDC42 in human ovarian cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2019
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300554(((2S,3R,4S,5S)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007190(CHEMBL3237589)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Rac1 in human MDA-MB-231 cells assessed as reduction in Rac-GTP level after 24 hrs by ELISA-based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300547(2,3,9,10-Tetrahydroxy-5,6-dihydro-isoquino[3,2-a]i...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300551(2,3,7,8-Tetrahydroxy-5-methyl-benzo[c]phenanthridi...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50391235(CHEMBL3216441)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Rac1 GTPase in human MDA-MB-435 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50293841(3-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-methyl...)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50468262(CHEMBL4277903)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of Rac1 GTPase in human MDA-MB-231 cells assessed as inhibition of cell proliferation treated for 72 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50293840(N-(4-methoxy-3-(piperidin-1-ylsulfonyl)phenyl)-1H-...)
Affinity DataIC50: 2.41E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50293842(1-(4-morpholinophenylamino)-1-oxopropan-2-yl 1-hyd...)
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300545(tetrahydroxycanadine hydrochloride | CHEMBL573174)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300548(3,4,10,11-Tetrahydroxy-8-methyl-isoquino[3,2-a]iso...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50293843(CHEMBL550826 | cid_2999946 | 1,8-diamino-6-methoxy...)
Affinity DataIC50: 4.61E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300552(2,3-Dihydroxy-7,8-dimethoxy-5-methyl-benzo[c]phena...)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50293839(2-(4-fluoro-3-nitrophenylamino)-N-(4-morpholinophe...)
Affinity DataIC50: 5.72E+4nMAssay Description:Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300546(6,7-Dimethoxy-1-methyl-3-naphthalen-2-yl-isoquinol...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM25525(CHEMBL490129 | 24-methyl-5,7,18,20-tetraoxa-24-aza...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300549(2,3-Dihydroxy-9,10-dimethoxy-5,6-dihydro-isoquino[...)
Affinity DataIC50: 6.30E+4nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50007189(CHEMBL3237582)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM25524(CHEMBL13045 | 17,18-dimethoxy-21-methyl-5,7-dioxa-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetRas-related C3 botulinum toxin substrate 1(Human)
Shanghai Jiao Tong University

Curated by ChEMBL
LigandPNGBDBM50300550(3-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-1-methyl-is...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of Rac1 GTPase activity assessed as incorporation of BODIPY-GTP after 40 mins by nucleotide binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed