Compile Data Set for Download or QSAR
Report error Found 952 of affinity data for UniProtKB/TrEMBL: P51639
LigandPNGBDBM50013219(CHEMBL2375155 | Sodium salt of7-[1-Cyclohexyl-4-(4...)
Affinity DataIC50: 0.106nMAssay Description:In vitro inhibition of HMG-CoA reductase of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042653(7-[3-Bromo-4,5-bis-(4-fluoro-phenyl)-2-isopropyl-p...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22158((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(1-methy...)
Affinity DataIC50: 0.5nM EC50:  1.40nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM50042654(7-[3-(3-Bromo-phenyl)-2-(4-fluoro-phenyl)-5-isopro...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM18382(disodium 4-[({5-[(3R,5R)-6-carboxylato-3,5-dihydro...)
Affinity DataIC50: 0.850nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
LigandPNGBDBM22157((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-methyl-1H-1...)
Affinity DataIC50: 0.900nM EC50:  1.5nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM22160(sodium 5-({5-[(1E,3S,5R)-6-carboxy-3,5-dihydroxyhe...)
Affinity DataIC50: 0.900nM EC50:  13.7nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM50003240(2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-te...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of rat liver HMG-CoA reductase pre incubated for 5 mins followed by substrate addition using NADPH as substrate by scintillation counter a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM155374(US9006282, Example 2, Compound 2 | US9102656, Exam...)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155376(US9006282, Example 2, Compound 4 | US9102656, Exam...)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155380(US9006282, Example 2, Compound 8 | US9102656, Exam...)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155384(US9006282, Example 3, Compound 3)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155385(US9006282, Example 3, Compound 4)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155386(US9006282, Example 3, Compound 5)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155389(US9006282, Example 3, Compound 8)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM155390(US9006282, Example 3, Compound 9)
Affinity DataIC50: 1nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2015
Entry Details
Go to US Patent

LigandPNGBDBM50014840(CHEMBL2368197 | (E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50014828(CHEMBL2368185 | (E)-6-{2-[2,4-Bis-(4-fluoro-phenyl...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50014820(CHEMBL2368189 | (E)-6-{2-[2-Cyclohexyl-4-(4-fluoro...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50020287(7-[2,6-Dimethyl-8-(2-methyl-butyryloxy)-1,2,4a,5,6...)
Affinity DataIC50: 1nMAssay Description:Ability of compound to inhibit the activity of 3-hydroxy-3-methylglutarylcoenzyme A(HMGR) reductase in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042607((E)-(3R,5S)-7-[4,5-Bis-(4-fluoro-phenyl)-2-isoprop...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042625((E)-(3R,5S)-7-[2,4-Bis-(4-fluoro-phenyl)-5-isoprop...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50042631(CHEMBL121727 | (E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50231035(sodium; (3R,5R)-7-[3-(3-carbamoylmethyl-phenylsulf...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM18425((3R,5R)-7-[1-(4-fluorophenyl)-3-{[(4-methylphenyl)...)
Affinity DataIC50: 1nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50007295(CHEMBL2367823 | Sodium; 7-[4-(4-fluoro-phenyl)-2,6...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of solubilized HMG-CoA reductase in rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50346282(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346283(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346286(sodium(3R,5R)-7-(5-cyclopropyl-4-(3-fluorobenzylca...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346288(sodium(3R,5R)-7-(5-cyclopropyl-4-(3,4-difluorobenz...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346289(sodium(3R,5R)-7-(5-cyclopropyl-4-(2,4-difluorobenz...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50020291(CHEMBL60053 | 3-Hydroxy-5-oxo-7-phenyl-heptanoic a...)
Affinity DataIC50: 1.30nMAssay Description:Ability of compound to inhibit the activity of 3-hydroxy-3-methylglutarylcoenzyme A(HMGR) reductase in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM22163(sodium (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[methyl(...)
Affinity DataIC50: 1.40nM EC50:  3.95nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM50346278(sodium(3R,5R)-7-(4-(benzylcarbamoyl)-5-cyclopropyl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50226270(CHEMBL3349956)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50226272(CHEMBL3349944)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20708(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{methyl[(1R...)
Affinity DataIC50: 1.5nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
LigandPNGBDBM20712(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-[(3-phenylp...)
Affinity DataIC50: 1.5nM EC50:  0.400nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
LigandPNGBDBM50346287(sodium(3R,5R)-7-(5-cyclopropyl-4-(2-fluorobenzylca...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM18384(sodium (3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-5-{[(...)
Affinity DataIC50: 1.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
LigandPNGBDBM18387(sodium (3R,5R)-7-[1-ethyl-3-(4-fluorophenyl)-5-({[...)
Affinity DataIC50: 1.60nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
LigandPNGBDBM50020290(CHEMBL59166 | 7-[2,6-Dimethyl-8-(2-methyl-butyrylo...)
Affinity DataIC50: 1.60nMAssay Description:Ability of compound to inhibit the activity of 3-hydroxy-3-methylglutarylcoenzyme A(HMGR) reductase in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50346279(sodium(3R,5R)-7-(5-cyclopropyl-2-(4-fluorophenyl)-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of HMG-CoA reductase in Sprague-Dawley rat liver microsomes using [14C]HMG-CoA as substrate preincubated for 0.5 hrs before substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM22154((3R,5S,6E)-7-[4-(4-fluorophenyl)-2-[(1-methyl-1H-p...)
Affinity DataIC50: 1.80nM EC50:  3.70nMpH: 7.0 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2008
Entry Details Article
PubMed
LigandPNGBDBM50231037(sodium (3R,5R)-7-(3-(azetidin-1-ylsulfonyl)-5-(4-f...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of rat microsomal HMGCoA reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM20692(pyrazole-based inhibitor, 35 | sodium (3R,5R)-7-[1...)
Affinity DataIC50: 1.90nM EC50:  0.900nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
LigandPNGBDBM50226271(CHEMBL3349955)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM20713(sodium (3R,5R)-7-[1-(4-fluorophenyl)-3-{[(3R)-3-ph...)
Affinity DataIC50: 2nM EC50:  0.300nMpH: 7.2 T: 2°CAssay Description:Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed
LigandPNGBDBM18390((3R,5S)-6-[(3-{[(2,3-difluorophenyl)methyl]carbamo...)
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
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