Compile Data Set for Download or QSAR
Report error Found 140 for UniProtKB: P51160
LigandPNGBDBM50560848(4-Methoxyevodiamine | CHEMBL2171791)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50560849(CHEMBL4782533)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50016250(CHEMBL81925)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of human PDE6C (2-854 residues) expressed in Sf9 cells incubated for 15 mins using [3H]-cGMP as substrate by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50196772(CHEMBL3936651)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of recombinant N-terminal GST tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 cells using cGMP as substrate by malachi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
LigandPNGBDBM50459162(CHEMBL4218772)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PDE6C catalytic domain (1 to 858 residues) (unknown origin) expressed in Escherichia coli BL21 using 3H-cGMP as substrate after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458313(CHEMBL4217054)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458479(CHEMBL4212186)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PDE6C (unknown origin) using FAM-cGMP as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458314(CHEMBL4217579)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50492928(CHEMBL2414311)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
LigandPNGBDBM50458305(CHEMBL4212630)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50196675(CHEMBL3900593)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant N-terminal GST tagged PDE6C (unknown origin) expressed in baculovirus infected Sf9 cells using cGMP as substrate by malachi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
LigandPNGBDBM50458306(CHEMBL4218398)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458318(CHEMBL4208249)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50458312(CHEMBL4209716)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50067186(CHEMBL3401745)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of PDE6C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50458316(CHEMBL4204725)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50241840(CHEMBL4072903 | US10899756, Compound K)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant PDE6C using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50399897(CHEMBL2180942)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126469((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-propyl-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50467475(CHEMBL4284224)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM14776(CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM50467486(CHEMBL4285199)
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50525060(CHEMBL4462192)
Affinity DataIC50: 20nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 24nMAssay Description:Inhibition of PDE6C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
LigandPNGBDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant PDE6C using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50241831(CHEMBL4062273 | US10899756, Compound U | US1062611...)
Affinity DataIC50: 30nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50458304(CHEMBL4205338)
Affinity DataIC50: 34nMAssay Description:Inhibition of N-terminal GST-tagged full length recombinant human PDE6C expressed in Baculovirus infected Sf9 insect cells using FAM-cAMP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal GST-tagged human PDE6C expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50399909(CHEMBL2180945)
Affinity DataIC50: 46nMAssay Description:Inhibition of human recombinant PDE6C at 1 uM by [3H]cGMP based tritium scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50467477(CHEMBL4277243)
Affinity DataIC50: 56nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50193586(7-benzyl-4-isopropyl-9-methyl-2-phenyl-7H-3,3a,5,7...)
Affinity DataIC50: 62nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50467473(CHEMBL4292389)
Affinity DataIC50: 62nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467476(CHEMBL4280648)
Affinity DataIC50: 107nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126462((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1-m...)
Affinity DataIC50: 125nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126462((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1-m...)
Affinity DataIC50: 125nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50467472(CHEMBL4281766)
Affinity DataIC50: 127nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM50467474(CHEMBL4289471)
Affinity DataIC50: 136nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human PDE6CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126452((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Affinity DataIC50: 226nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126458((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-benzyl-...)
Affinity DataIC50: 249nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50467478(CHEMBL4287438)
Affinity DataIC50: 253nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50126455((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Affinity DataIC50: 271nMAssay Description:Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retinaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50193569(7-benzyl-4,9-dimethyl-2-pyridin-3-yl-7H-3,3a,5,7,8...)
Affinity DataIC50: 280nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50467489(CHEMBL4292970)
Affinity DataIC50: 288nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE6C expressed in baculovirus infected sf9 cells using FAM-cyclic-3',5-AMP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50193574(7-benzyl-2-furan-3-yl-4,9-dimethyl-7H-3,3a,5,7,8-p...)
Affinity DataIC50: 330nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50193577(3-benzyl-1-ethoxymethyl-6-methyl-9-phenylpyrazolo[...)
Affinity DataIC50: 330nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50428976(CHEMBL2333219)
Affinity DataIC50: 339nMAssay Description:Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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