Compile Data Set for Download or QSAR
Report error Found 261 of affinity data for UniProtKB/TrEMBL: P48450
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50548147(CHEMBL4785476)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to human wild-type SUMO-tagged catechol O-methyltransferase assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50548148(CHEMBL4782173)
Affinity DataKd:  1.80E+4nMAssay Description:Binding affinity to human wild-type SUMO-tagged catechol O-methyltransferase assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50548149(CHEMBL4764231)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to human wild-type SUMO-tagged catechol O-methyltransferase assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50108877(CHEMBL1324 | Tasmar | Ro-40-7592 | (3,4-dihydroxy-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450452(CHEMBL4167128)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450454(CHEMBL4174978)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450473(CHEMBL4170443)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450450(CHEMBL4172614)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450447(CHEMBL4171117)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450468(CHEMBL4169861)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450465(CHEMBL4177089)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529561(CHEMBL4462175)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450462(CHEMBL4160303)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450467(CHEMBL4163421)
Affinity DataIC50: 10nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529577(CHEMBL4470211)
Affinity DataIC50: 10nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529578(CHEMBL4461693)
Affinity DataIC50: 10nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529585(CHEMBL4458006)
Affinity DataIC50: 13nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529576(CHEMBL4531460)
Affinity DataIC50: 16nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450449(CHEMBL4174117)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450453(CHEMBL4174102)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450448(CHEMBL4176008)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450453(CHEMBL4174102)
Affinity DataIC50: 20nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50167084(CHEMBL3798524)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529575(CHEMBL4449462)
Affinity DataIC50: 38nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50167074(CHEMBL3799913)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529571(CHEMBL4453736)
Affinity DataIC50: 40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529572(CHEMBL4583818)
Affinity DataIC50: 40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529574(CHEMBL4447751)
Affinity DataIC50: 40nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50133285((E)-3-Carboxy-acrylateallyl-{6-[4-(4-chloro-benzoy...)
Affinity DataIC50: 49nMAssay Description:Tested for Oxidosqualene-lanosterol cyclase inhibition in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50055641(3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl...)
Affinity DataIC50: 50nMAssay Description:Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50167085(CHEMBL3799623)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50055641(3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat OSCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50213692(2,2-dimethyl-3-((E)-3-methyl-7-((3E,8E)-4,8,12-tri...)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat OSCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50213696(3-((3E,7E)-11-((E)-4,8-dimethylnona-4,7-dienylthio...)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat OSCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450469(CHEMBL4162990)
Affinity DataIC50: 50nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529570(CHEMBL4476127)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529573(CHEMBL4523002)
Affinity DataIC50: 50nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50180953(CHEMBL3818719)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant His-tagged soluble COMT expressed in Escherichia coli BL21 using aesculetin as substrate after 60 mins by microplate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2017
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50167078(CHEMBL3800198)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 58nMAssay Description:In vitro percent inhibitory activity of the compound against rat microsomal OSC enzyme at 1 uM concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50095601([4-(1-Aza-bicyclo[2.2.2]oct-3-yloxy)-phenyl]-(4-ch...)
Affinity DataIC50: 58nMAssay Description:Concentration for the inhibition of rat microsomal oxidosqualene cyclase-lanosterol synthase (OSC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529580(CHEMBL4556206)
Affinity DataIC50: 60nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450470(CHEMBL4166574)
Affinity DataIC50: 63nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50529560(CHEMBL4577912)
Affinity DataIC50: 63nMAssay Description:Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50542443(CHEMBL4639358)
Affinity DataIC50: 70nMAssay Description:Inhibition of COMT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50548126(CHEMBL4755152)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant wild-type human COMT expressed in Escherichia coli BL21 using 4-nitrocatechol-Alexa488 as substrate in presence of cofactor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50450464(CHEMBL4176890)
Affinity DataIC50: 79nMAssay Description:Inhibition of c-terminal hexa-His tagged human MB-COMT expressed in HEK293 cell membrane homogenate using norepinephrine as substrate after 1 hr in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50095600([4-(4-Iodo-benzenesulfonyl)-piperazin-1-yl]-(3,4,5...)
Affinity DataIC50: 82nMAssay Description:In vitro inhibitory activity of the compound against rat microsomal 2,3-Oxidosqualene cyclase-Lanosterol synthase (OSC)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLanosterol synthase(Rat)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50167083(CHEMBL3800482)
Affinity DataIC50: 84nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged MB-COMT expressed in Bacmid using SAM/dopamine as substrate preincubated for 2 hrs followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2017
Entry Details Article
PubMed
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