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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50462395(CHEMBL4238437)
Affinity DataKd:  5.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50636053(CHEMBL5555217)
Affinity DataKd:  2.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50636055(CHEMBL5557454)
Affinity DataKd:  3.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataKd:  69nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427628(CHEMBL2323472 | US9346803, Table 2, Compound 8: 2-...)
Affinity DataIC50: 0.120nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)
Affinity DataIC50: 0.130nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427629(CHEMBL179587 | US9346803, Table 2, Compound 7: 2-[...)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)
Affinity DataIC50: 0.160nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427621(CHEMBL2323490 | US9346803, 1)
Affinity DataIC50: 0.210nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427625(CHEMBL178687 | US9346803, Table 2, Compound 6: 3-[...)
Affinity DataIC50: 0.220nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427627(CHEMBL2323474 | US9346803, Table 2, Compound 9: 2-...)
Affinity DataIC50: 0.270nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50438582(CHEMBL2413849)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human 17beta-HSD5 expressed in HEK293 cells using androstenedione as substrate assessed as testosterone synthesis after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)
Affinity DataIC50: 0.340nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3/Glutathione S-transferase P(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM254841(US9487554, 28)
Affinity DataIC50: 0.5nMpH: 7.0Assay Description:Essentially, the enzyme activity is measured by quantification of the Coumberol from Coumberone (Halim, M., Yee, D. J., and Sames, D., J. AM. CHEM. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313838(US10167293, Example 31)
Affinity DataIC50: 0.5nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313874(US10167293, Example 65)
Affinity DataIC50: 0.5nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313879(US10167293, Example 70)
Affinity DataIC50: 0.5nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313837(US10167293, Example 30)
Affinity DataIC50: 0.600nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313878(US10167293, Example 69)
Affinity DataIC50: 0.600nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313839(US10167293, Example 32)
Affinity DataIC50: 0.700nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313884(sodium 5-({8-[(3,5-difluorophenyl)sulfonyl]-3,8-di...)
Affinity DataIC50: 0.700nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50427626(CHEMBL2323481 | US9346803, Table 2, Compound 5: 2-...)
Affinity DataIC50: 0.740nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3/Glutathione S-transferase P(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM254826(US9487554, 13)
Affinity DataIC50: 0.800nMpH: 7.0Assay Description:Essentially, the enzyme activity is measured by quantification of the Coumberol from Coumberone (Halim, M., Yee, D. J., and Sames, D., J. AM. CHEM. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313859(US10167293, Example 51)
Affinity DataIC50: 0.800nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313861(US10167293, Example 53)
Affinity DataIC50: 0.800nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313880(US10167293, Example 71)
Affinity DataIC50: 0.800nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313816(US10167293, Example 9)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313834(US10167293, Example 27)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313836(US10167293, Example 29)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313854(US10167293, Example 46)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313858(US10167293, Example 50)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313875(US10167293, Example 66)
Affinity DataIC50: 0.900nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM50293598(2'-des-methyl indomethacin | CHEMBL503179 | US9346...)
Affinity DataIC50: 0.960nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2017
Entry Details
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PDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313809(US10167293, Example 2 | 1H-1,2,3-triazol-4-yl[8-{[...)
Affinity DataIC50: 1nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313825(US10167293, Example 18)
Affinity DataIC50: 1nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313827(US10167293, Example 20)
Affinity DataIC50: 1nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313876(US10167293, Example 67)
Affinity DataIC50: 1nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
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TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313818(US10167293, Example 11)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313819(US10167293, Example 12)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313826(US10167293, Example 19)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313833(US10167293, Example 26)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313850(US10167293, Example 42)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313856(US10167293, Example 48)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313881(US10167293, Example 72)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313885(sodium 5-({8-[(3-fluorophenyl)sulfonyl]-3,8-diazab...)
Affinity DataIC50: 1.10nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3/Glutathione S-transferase P(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM254825(US9487554, 12)
Affinity DataIC50: 1.20nMpH: 7.0Assay Description:Essentially, the enzyme activity is measured by quantification of the Coumberol from Coumberone (Halim, M., Yee, D. J., and Sames, D., J. AM. CHEM. S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313811(US10167293, Example 4 | {8-[(3-fluorophenyl)sulfon...)
Affinity DataIC50: 1.20nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313812(US10167293, Example 5)
Affinity DataIC50: 1.20nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetAldo-keto reductase family 1 member C3(Human)
University of Turin

Curated by ChEMBL
LigandPNGBDBM313835(US10167293, Example 28)
Affinity DataIC50: 1.20nMAssay Description:The enzyme used was recombinant human AKR1C3 (Aldo-keto reductase family 1 member C3; GenBank Accession No. NM_003739). This was expressed in E. coli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

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