Compile Data Set for Download or QSAR
Report error Found 149 of affinity data for UniProtKB/TrEMBL: P42226
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50401024(CHEMBL2204366)
Affinity DataKd:  701nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50401025(CHEMBL2203687)
Affinity DataKd:  7.40E+4nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50401026(CHEMBL2204367)
Affinity DataKd:  656nMAssay Description:Binding affinity at human recombinant STAT6 by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50557878(CHEMBL4776801)
Affinity DataKd: >10nMAssay Description:Binding affinity to human recombinant STAT6 assessed as dissociation constant incubated for 15 mins by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243934(CHEMBL487451 | CHEMBL488307 | AS-1617612 | 2-[(4-M...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304425(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244291(4-[(2-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243884(4-[(2,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243933(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2,3,5-triflu...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244292(4-[(3-Fluorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304429(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243882(4-[(2,3-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243885(4-[(2,6-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304433(7-(3,5-Difluorobenzyl)-N-[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304428(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243932(4-[(3,5-Difluorobenzyl)amino]-2-[(4-morpholin-4-yl...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304432(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244256(4-Benzylamino-2-{[4-(4-methylpiperazin-1-yl)phenyl...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244258(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244257(4-Benzylamino-2-[(4-piperazin-1-ylphenyl)amino]-py...)
Affinity DataIC50: 7nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244331(4-[(2-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244329(4-[(2-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244294(4-[(2-Methylbenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 11nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304434(7-(3,5-Difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244223(4-Benzylamino-2-{[4-(4-hydroxypiperidin-1-yl)pheny...)
Affinity DataIC50: 16nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244259(4-Benzylamino-2-{[4-(1-methylpiperidin-4-yl)phenyl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243794(4-[(3-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50: 19nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50614612(CHEMBL5280678)
Affinity DataIC50: 20nMAssay Description:Inhibition of IL-4 induced STAT6 signaling in human HepG2 cells harboring pRL-EF1alpha, pGL3-TK-7xN4 and TOPO-Stat6 plasmid assessed as luciferase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50614612(CHEMBL5280678)
Affinity DataIC50: 20nMAssay Description:Inhibition of IL-4 induced STAT6 signaling in human HepG2 cells harboring pRL-EF1alpha, pGL3-TK-7xN4 and TOPO-Stat6 plasmid assessed as luciferase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50197554(AS-1517499 | 4-(benzylamino)-2-{[2-(3-chloro-4-hyd...)
Affinity DataIC50: 21nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50197554(AS-1517499 | 4-(benzylamino)-2-{[2-(3-chloro-4-hyd...)
Affinity DataIC50: 21nMAssay Description:Inhibition of STAT6 in human IL4-stimulated FW4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244330(4-[(2-Hydroxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50: 22nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244369(4-{[2-(Methylsulfanyl)benzyl]amino}-2-[(4-morpholi...)
Affinity DataIC50: 23nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243725(4-[(3-Methoxybenzyl)amino]-2-[(4-morpholin-4-ylphe...)
Affinity DataIC50: 25nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244332(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-trifluorom...)
Affinity DataIC50: 25nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304430([4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]-p...)
Affinity DataIC50: 26nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50499614(CHEMBL3741938)
Affinity DataIC50: 28nMAssay Description:Inhibition of STAT6 (unknown origin) expressed in Escherichia coli using FAM-Ala-pTyr-Lys-ProPhe-Gln-Asp-Leu-Ile-NH2 as substrate by fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50370949(CHEMBL226930)
Affinity DataIC50: 30nMAssay Description:Inhibition of STAT6 in human IL4-stimulated FW4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304431(N-{4-[4-(2-Aminoethyl)piperazin-1-yl]phenyl}-7-(3,...)
Affinity DataIC50: 34nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50243723(4-[(3-Chlorobenzyl)amino]-2-[(4-morpholin-4-ylphen...)
Affinity DataIC50: 36nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50304435(7-(3-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)
Affinity DataIC50: 37nMAssay Description:Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244366(2-[(4-Morpholin-4-ylphenyl)amino]-4-[(2-nitrobenzy...)
Affinity DataIC50: 38nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50499605(CHEMBL3741162)
Affinity DataIC50: 44nMAssay Description:Inhibition of STAT6 (unknown origin) expressed in Escherichia coli using FAM-Ala-pTyr-Lys-ProPhe-Gln-Asp-Leu-Ile-NH2 as substrate by fluorescence pol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50370952(CHEMBL228018)
Affinity DataIC50: 45nMAssay Description:Inhibition of STAT6 in human IL4-stimulated FW4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50621289(CHEMBL5410106)
Affinity DataIC50: 50nMAssay Description:Inhibition of IL-4 induced STAT6 signaling in human HepG2 cells harboring pRL-EF1alpha, pGL3-TK-7xN4 and TOPO-Stat6 plasmid assessed as luciferase ac...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50614610(CHEMBL5267203)
Affinity DataIC50: 56nMAssay Description:Inhibition of IL-4 induced STAT6 signaling in human HepG2 cells harboring pRL-EF1alpha, pGL3-TK-7xN4 and TOPO-Stat6 plasmid assessed as luciferase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50614610(CHEMBL5267203)
Affinity DataIC50: 56nMAssay Description:Inhibition of IL-4 induced STAT6 signaling in human HepG2 cells harboring pRL-EF1alpha, pGL3-TK-7xN4 and TOPO-Stat6 plasmid assessed as luciferase ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50244189(4-(Benzylamino)-2-{[2-(3,5-dichloro-4-hydroxypheny...)
Affinity DataIC50: 61nMAssay Description:Inhibition of STAT6 activation in FW4 reporter cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 6(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50370950(CHEMBL387668)
Affinity DataIC50: 64nMAssay Description:Inhibition of STAT6 in human IL4-stimulated FW4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
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