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Report error Found 1113 of affinity data for UniProtKB/TrEMBL: P39900
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM29019((1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM29020((1S,5S,7R)-3-benzyl-6,8-dioxa-3-azabicyclo[3.2.1]o...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM29021((1R,5S,7R)-3-benzyl-N-hydroxy-2-oxo-6,8-dioxa-3-az...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM29022(ethyl 1-(hydroxycarbamoyl)piperidine-4-carboxylate...)
Affinity DataKd:  3.40E+6nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM29023((1S,5R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-aza...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50246196(CHEMBL4065195)
Affinity DataKd:  8.75E+5nMAssay Description:Binding affinity to human 15N-labeled MMP-12 catalytic domain (G106 to G263 residues) expressed in Escherichia coli BL21 Gold by 1H NSQC NMR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2019
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50287585(CHEMBL4169775)
Affinity DataKd: <50nMAssay Description:Binding affinity to recombinant human MMP12 catalytic domain (Gly106 to Gly26 residues) expressed in Escherichia coli BL21 codon plus by 1D 1H alipha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50287585(CHEMBL4169775)
Affinity DataKd: <50nMAssay Description:Binding affinity to recombinant human MMP12 catalytic domain (Gly106 to Gly26 residues) expressed in Escherichia coli BL21 codon plus by 2D [15N,1H] ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360964(CHEMBL1935285)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360965(CHEMBL1935286)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50161330((R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-h...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 4 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360966(CHEMBL1935287)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360967(CHEMBL1935288)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50148216(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360956(CHEMBL1935304)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50610465(CHEMBL5288452)
Affinity DataIC50: 0.368nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50295489((S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360963(CHEMBL1935284)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360968(CHEMBL1935290)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50610466(CHEMBL5280430)
Affinity DataIC50: 0.566nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360959(CHEMBL1935280)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 1 hr preincubation by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50299051(N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfon...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of autoactivated human pro-MMP12 after 30 mins preincubation by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50: 0.900nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50428828(CHEMBL2337131)
Affinity DataIC50: 0.930nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50151732(4-[4-(2,4-Dichloro-benzyloxy)-benzenesulfonyl]-3-h...)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of matrix metalloprotease 12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50026624(CHEMBL1935289)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360969(CHEMBL1935291)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP12 using Mca-PQGL-(3-[2, 4-dinitrophenyl]-L-2, 3-diaminopropionyl)-AR-OH as substrate after 2 to 4 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2019
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605508(US11673884, Compound AC-2)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605509(US11673884, Compound AC-3)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605512(US11673884, Compound AC-5)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605513(US11673884, Compound AC-6)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605515(US11673884, Compound AC-8)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605516(US11673884, Compound AC-9)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605517(US11673884, Compound AC-10)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605518(US11673884, Compound AC-11)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM605519(US11673884, Compound AC-12)
Affinity DataIC50: 1nMAssay Description:The inhibitory effect of compounds on the rate of cleaving fluorogenic MMP substrate (Enzo, BML-P128) by recombinant human MMP-12 catalytic domain (E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent

TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360970(CHEMBL1935292)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50592903(CHEMBL5199189)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of MMP-12 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50606384(CHEMBL5183245)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 1.40nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50295479((S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50360952(CHEMBL1935300)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

LigandPNGBDBM50129986(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
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