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Report error Found 1733 of affinity data for UniProtKB/TrEMBL: P37136
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50020522(1-(((4-carbamoylpyridinium-1-yl)methoxy)methyl)-2-...)
Affinity DataKd:  2.40E+4nMAssay Description:Binding affinity to AChE in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50011780(Pralidoxine chloride | PRALIDOXIME | CHEMBL748 | 2...)
Affinity DataKd:  2.10E+5nMAssay Description:Binding affinity to AChE in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKoff:  567s-1Assay Description:Inhibition of rat brain AChE by time-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50490822(2-Fluoroethyl 4-Nitrophenyl Methylphosphonate | CH...)
Affinity DataKoff:  1.03E+3s-1Assay Description:Inhibition of rat brain AChE by time-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50490821(2-Fluoroethyl 4-Nitrophenyl Ethylphosphonate | CHE...)
Affinity DataKoff:  200s-1Assay Description:Inhibition of rat brain AChE by concentration-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKoff:  267s-1Assay Description:Inhibition of rat brain AChE by concentration-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50490822(2-Fluoroethyl 4-Nitrophenyl Methylphosphonate | CH...)
Affinity DataKoff:  1.02E+3s-1Assay Description:Inhibition of rat brain AChE by concentration-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50490821(2-Fluoroethyl 4-Nitrophenyl Ethylphosphonate | CHE...)
Affinity DataKoff:  633s-1Assay Description:Inhibition of rat brain AChE by time-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9054(6-chloro-N-{7-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50: 0.0700nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50235322(CHEMBL4066593)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50235323(CHEMBL4080023)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9055(6-chloro-N-{8-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50235324(CHEMBL4104258)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of rat cortex AchE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50037158(Methyl-carbamic acid 3-({ethyl-[5-(5-nitro-1,3-dio...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition concentration against rat acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50149212(N-(1,2,3,4,8a,10a-Hexahydro-acridin-9-yl)-N'-(1,2,...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory concentration against Acetylcholinesterase in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate measured after 8 mins in presence of BuChE inhibitor ethopropazine by Ellma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of AChE in rat brain cortex using acetylthiocholine iodide as substrate incubated for 8 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50398922(CHEMBL2178790)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9051(6-fluoro-N-{7-[(6-fluoro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9053(6-chloro-N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50: 0.600nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | N-[8-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 0.680nMAssay Description:Inhibitory concentration in vitro and ex vivo for anti-AChE activity in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9052(6-fluoro-N-{8-[(6-fluoro-1,2,3,4-tetrahydroacridin...)
Affinity DataIC50: 0.700nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM10469(CHEMBL424707 | Bis-THA inhibitor 8 | N-[9-(1,2,3,4...)
Affinity DataIC50: 0.770nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM10469(CHEMBL424707 | Bis-THA inhibitor 8 | N-[9-(1,2,3,4...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50273221(2-(4-(3-(Diethylamino)propanoyl)phenoxy)-5,6-dimet...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of AchE in rat cortex by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50568800(CHEMBL4859647)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9050(Hexylene-Linked Bis-(6-fluoro)tacrine | 6-fluoro-N...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50582079(CHEMBL5091959)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50568792(CHEMBL4846450)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50004000(CHEMBL94 | physostigmine | Antilirium | Eserine | ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat brain AChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50398924(CHEMBL2178788)
Affinity DataIC50: 1.03nMAssay Description:Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50398928(CHEMBL2178784)
Affinity DataIC50: 1.16nMAssay Description:Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9057(N,N-Bis-(1,2,3,4-tetrahydro-cyclohexa[1,2,-b]pyrid...)
Affinity DataIC50: 1.30nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50398923(CHEMBL2178789)
Affinity DataIC50: 1.33nMAssay Description:Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9047(CHEMBL73800 | N-[6-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 1.40nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 1.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50040619(1-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-3-(3-nitro-b...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition against acetylcholinesterase (AChE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat brain AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9426(N-9-(1,2,3,4-Tetrahydroacridinyl)-1,8-diamino-octa...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | N-[8-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM9061(N-(8-{6H,7H,8H,9H,10H-cyclohepta[b]quinolin-11-yla...)
Affinity DataIC50: 1.60nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50231951(2,5-bis(6-((2-methoxybenzyl)(ethyl)amino)hexylamin...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 1.70nMAssay Description:In vitro inhibitory effect on rat AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Rat)
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM50398927(CHEMBL2178785)
Affinity DataIC50: 1.79nMAssay Description:Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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