Compile Data Set for Download or QSAR
Report error Found 127 of affinity data for UniProtKB/TrEMBL: P35918
LigandPNGBDBM50181308(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse VEGFR-2 (785 to 1376 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
LigandPNGBDBM50181319(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181313(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181311(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)q...)
Affinity DataIC50: 4nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185178(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2008
Entry Details Article
PubMed
LigandPNGBDBM50181312(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50375204(CHEMBL444105)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50375193(CHEMBL269924)
Affinity DataIC50: 10nMAssay Description:Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50181303(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | Vargatef | US10981896, Co...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50181320(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50279080(methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
LigandPNGBDBM50376359(CHEMBL260092)
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2007
Entry Details Article
PubMed
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse FLK1 (785 to 1367 residues) expressed in sf9 cells after 1.5 to 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
LigandPNGBDBM50181314(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185184(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181315(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181305(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Affinity DataIC50: 25nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181305(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Affinity DataIC50: 25nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185172(2-(6-fluoro-1H-indazol-3-yl)-5-(4-(piperidin-1-yl)...)
Affinity DataIC50: 28nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185182(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185183(methyl 3-(5-(4-(piperidin-1-yl)piperidin-1-yl)-1H-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181307(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613385(CHEMBL5288744)
Affinity DataIC50: 37nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50185169(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Affinity DataIC50: 44nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185171(N-(cyclohexylmethyl)-3-(5-(4-(piperidin-1-yl)piper...)
Affinity DataIC50: 44nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50376355(CHEMBL412102)
Affinity DataIC50: 49nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50375203(CHEMBL271861)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse VEGFR2 autophosphorylation in NIH3T3 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50376363(CHEMBL409872)
Affinity DataIC50: 50nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50185181(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Affinity DataIC50: 52nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50376353(CHEMBL403706)
Affinity DataIC50: 52nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50377352(BMS-645737 | CHEMBL261592)
Affinity DataIC50: 53nMAssay Description:Inhibition of mouse Flk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50: 55nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50181306(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50: 57nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185173(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50375652(CHEMBL408565)
Affinity DataIC50: 70nMAssay Description:Inhibition of mouse KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50408947(CHEMBL103211)
Affinity DataIC50: 71nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 73nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50185170(2-(1H-indazol-3-yl)-5-(4-(piperidin-1-yl)piperidin...)
Affinity DataIC50: 78nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50185188(5-(1H-imidazol-1-yl)-2-(1H-indazol-3-yl)-1H-benzo[...)
Affinity DataIC50: 83nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50184807((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-me...)
Affinity DataIC50: 89nMAssay Description:Inhibitory activity against Flk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181302(4-amino-5-(1H-benzo[d]imidazol-2-yl)thieno[2,3-b]p...)
Affinity DataIC50: 109nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50181317(3-(1H-benzo[d]imidazol-2-yl)-4-hydroxyquinolin-2(1...)
Affinity DataIC50: 114nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50376343(CHEMBL411903)
Affinity DataIC50: 121nMAssay Description:Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50613383(CHEMBL5280119)
Affinity DataIC50: 125nMAssay Description:Inhibition of mouse recombinant GST-fused VEGFR2 kinase domain expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50185174(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50408953(CHEMBL320186)
Affinity DataIC50: 141nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
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