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TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50291990(CHEMBL222944 | Tonocard | 2-Amino-N-(2,6-dimethyl-...)
Affinity DataEC50:  2.75E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50291989(CHEMBL387108 | (S)-2-amino-N-(2,6-dimethylphenyl)p...)
Affinity DataEC50:  2.24E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413841(CHEMBL472884)
Affinity DataEC50:  1.12E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413842(CHEMBL473498)
Affinity DataEC50:  9.12E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413843(CHEMBL502686)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413844(CHEMBL473499)
Affinity DataEC50:  4.07E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413845(CHEMBL473705)
Affinity DataEC50:  6.76E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413846(CHEMBL473706)
Affinity DataEC50:  2.82E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413847(CHEMBL484981)
Affinity DataEC50:  2.19E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413848(CHEMBL484996)
Affinity DataEC50:  6.76E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413849(CHEMBL484833)
Affinity DataEC50:  5.01E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413850(CHEMBL485002)
Affinity DataEC50:  2.00E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413851(CHEMBL519199)
Affinity DataEC50:  3.16E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413852(CHEMBL485003)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413853(CHEMBL485004)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413854(CHEMBL486721)
Affinity DataEC50:  2.29E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413855(CHEMBL501346)
Affinity DataEC50:  5.01E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135883((R)-1-(2,6-dimethylphenoxy)propan-2-amine | (2R)-1...)
Affinity DataEC50:  2.29E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135884((S)-1-(2,6-dimethylphenoxy)propan-2-amine | (S)-2-...)
Affinity DataEC50:  2.69E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135886((R)-2-(2,6-Dimethyl-phenoxy)-1-phenyl-ethylamine |...)
Affinity DataEC50:  3.02E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135880((S)-2-(2,6-Dimethyl-phenoxy)-1-phenyl-ethylamine |...)
Affinity DataEC50:  3.02E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413856(CHEMBL446777)
Affinity DataEC50:  5.75E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413857(CHEMBL474672)
Affinity DataEC50:  5.75E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413858(CHEMBL487338)
Affinity DataEC50:  2.40E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135877((R)-2-(4-Chloro-2,6-dimethyl-phenoxy)-1-phenyl-eth...)
Affinity DataEC50:  1.95E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135882((S)-2-(4-chloro-2,6-dimethylphenoxy)-1-phenylethan...)
Affinity DataEC50:  7.94E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413859(CHEMBL486315)
Affinity DataEC50:  3.72E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413860(CHEMBL501561)
Affinity DataEC50:  2.88E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135885((R)-2-(4-Chloro-2-methyl-phenoxy)-1-phenyl-ethylam...)
Affinity DataEC50:  1.51E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413861(CHEMBL486414)
Affinity DataEC50:  2.29E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135881((R)-2-(4-chlorophenoxy)-1-phenylethanamine | (R)-2...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135873((S)-2-(4-chlorophenoxy)-1-phenylethanamine | (S)-2...)
Affinity DataEC50:  3.02E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135878((R)-1-phenyl-2-(o-tolyloxy)ethanamine | (R)-1-Phen...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413862(CHEMBL486528)
Affinity DataEC50:  3.02E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413863(CHEMBL2021482)
Affinity DataEC50:  2.09E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413864(CHEMBL2021481)
Affinity DataEC50:  2.34E+5nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135874((R)-2-phenoxy-1-phenylethanamine | (R)-2-Phenoxy-1...)
Affinity DataEC50:  3.98E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50135879((S)-2-phenoxy-1-phenylethanamine | (S)-2-Phenoxy-1...)
Affinity DataEC50:  1.58E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413865(CHEMBL468775)
Affinity DataEC50:  2.34E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413866(CHEMBL485647)
Affinity DataEC50:  1.74E+4nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413867(CHEMBL483784)
Affinity DataEC50:  7.08E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413868(CHEMBL452986)
Affinity DataEC50:  4.68E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413869(CHEMBL448542)
Affinity DataEC50:  2.69E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50413870(CHEMBL444700)
Affinity DataEC50:  1.91E+3nMAssay Description:Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  4.50E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  47nMAssay Description:Binding affinity to human recombinant Nav1.4 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  28nMAssay Description:Binding affinity to human recombinant Nav1.4 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 4 subunit alpha(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
LigandPNGBDBM71381(US9694002, 440 | US9546164, 440)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2018
Entry Details
Go to US Patent

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