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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM82006(D-AP4 | D-APB | US9212196, L-AP4)
Affinity DataEC50:  1.03E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196906(US9212196, Derivative 2)
Affinity DataEC50:  4.20E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196907(US9212196, Derivative 3)
Affinity DataEC50:  4.70E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196908(US9212196, Derivative 4)
Affinity DataEC50:  9.00E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196909(US9212196, Derivative 5)
Affinity DataEC50:  5.95E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196914(US9212196, Derivative 10)
Affinity DataEC50:  1.84E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196915(US9212196, Derivative 11)
Affinity DataEC50:  3.80E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196917(US9212196, Derivative 13)
Affinity DataEC50:  5.40E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196932(US9212196, Derivative 28)
Affinity DataEC50:  2.50E+3nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM196934(US9212196, Derivative 30)
Affinity DataEC50:  1.30E+4nMAssay Description:Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2016
Entry Details
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TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50017269(CHEMBL3287724 | US10099993, Compound 73)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50022759(CHEMBL3298273)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at rat mGlu6 receptor expressed in HEK293 cells assessed as glutamate-induced GIRK channel-mediated thallium f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50069348((S)-2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl...)
Affinity DataEC50: >1.00E+6nMAssay Description:Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 6 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50069349((S)-2-Amino-2-benzyl-3-(3,5-dioxo-[1,2,4]oxadiazol...)
Affinity DataEC50: >1.00E+6nMAssay Description:Antagonistic activity against rat (mGluR) metabotropic glutamate receptor 6 stably expressed in chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  55nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50034503(DCG-IV | (2S,2'R,3'R)-2-(2',3')-dicarboxycycloprop...)
Affinity DataEC50:  4.00E+4nMAssay Description:Metabotropic glutamate receptor 6 antagonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50138783(4-((S)-Amino-carboxy-methyl)-phthalic acid | 4-[am...)
Affinity DataEC50:  3.60E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataEC50:  147nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50034504((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Affinity DataEC50:  600nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50004881(Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG) | (...)
Affinity DataEC50:  4.70E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50138781(2-(Amino-carboxy-methyl)-3-methyl-cyclopropanecarb...)
Affinity DataEC50:  1.20E+3nMAssay Description:Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50062522((1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  3.45E+3nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50088290(CHEMBL3427499)
Affinity DataEC50:  6.01E+3nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | D-Glu | D-Glutamat...)
Affinity DataEC50:  8.22E+4nMAssay Description:Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2016
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50191052((2S,4S)-4-amino-1-((E)-3-carboxyacryloyl)pyrrolidi...)
Affinity DataEC50:  3.78E+5nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50060137((1R,2S,4s)-4-aminocyclopentane-1,2,4-tricarboxylic...)
Affinity DataEC50:  1.84E+4nMAssay Description:Activity at rat mGluR6 receptor measured as intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  2.08E+3nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50174527(CHEMBL145114 | CHEMBL535153 | (S)-2-Amino-4-(hydro...)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50220009(L-(+)-2-amino-4-[(hydroxy)phosphinyl]butyric acid ...)
Affinity DataEC50:  2.78E+4nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50220011(L-(+)-2-amino-4-thiophosphonobutyric acid | CHEMBL...)
Affinity DataEC50:  730nMAssay Description:Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50134443(CHEMBL3746457)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50134466(CHEMBL3747116)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM66976(SMR001230688 | trans-( )-ACPD monohydrate | cid_16...)
Affinity DataEC50:  6.00E+4nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50071161(4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid...)
Affinity DataEC50:  2.00E+4nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50291320((2R,4R)-4-Benzoylamino-pyrrolidine-2,4-dicarboxyli...)
Affinity DataEC50:  1.00E+6nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50052398(2R, 4R-APDC | (2R,4R)-APDC | CHEMBL40086 | (2R,4R)...)
Affinity DataEC50:  1.10E+5nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50004051(CHEMBL285843 | 2-Amino-4-phosphono-butyric acid | ...)
Affinity DataEC50:  1.00E+3nMAssay Description:Tested for the agonistic activity against Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataEC50:  6.51E+4nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50252049((2S,4R)-4-(3-Hydroxy-3-oxopropyl)glutamic Acid | (...)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50159150(CHEMBL3787264)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50159146(CHEMBL3786938)
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50159147(CHEMBL3786026)
Affinity DataEC50:  1.78E+4nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50159148(CHEMBL3786667)
Affinity DataEC50:  490nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50007548(2-Amino-4-phosphono-butyric acid | 2-amino-4-phosp...)
Affinity DataEC50:  1.91E+3nMAssay Description:Agonist activity at rat mGlu6 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50102116((2R,4R)-4-amino-1-(2-nitrobenzyl)pyrrolidine-2,4-d...)
Affinity DataEC50:  1.10E+5nMAssay Description:Effective concentration required for agonistic activity at Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50102112((2R,4R)-4-amino-1-(4-methoxybenzyl)pyrrolidine-2,4...)
Affinity DataEC50:  3.20E+5nMAssay Description:Effective concentration required for agonistic activity at Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50102120((2R,4R)-4-amino-1-(2-hydroxybenzyl)pyrrolidine-2,4...)
Affinity DataEC50:  8.80E+4nMAssay Description:Effective concentration required for partial agonistic activity at Metabotropic glutamate receptor 6; Partial agonistMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Rat)
Universite Paris Descartes

US Patent
LigandPNGBDBM50102121((2R,4R)-4-amino-1-[carboxy(phenyl)methyl]pyrrolidi...)
Affinity DataEC50:  2.20E+4nMAssay Description:Effective concentration required for agonistic activity at Metabotropic glutamate receptor 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed
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