Compile Data Set for Download or QSAR
Report error Found 158 of affinity data for UniProtKB/TrEMBL: P34897
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  345nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  5.83E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285658(US10077273, Compound 4 | US10584132, Compound 4 | ...)
Affinity DataIC50: 0.170nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285658(US10077273, Compound 4 | US10584132, Compound 4 | ...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285659(US10077273, Compound 68 | US10584132, Compound 68 ...)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285659(US10077273, Compound 68 | US10584132, Compound 68 ...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285663(US10077273, Compound 11 | US10584132, Compound 11 ...)
Affinity DataIC50: 0.400nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285660(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Affinity DataIC50: 0.650nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285660(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285660(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Affinity DataIC50: 0.790nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285660(US10077273, Compound 1 | US10584132, Compound 1 | ...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285661(US10077273, Compound 69 | US10584132, Compound 69 ...)
Affinity DataIC50: 0.800nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285661(US10077273, Compound 69 | US10584132, Compound 69 ...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285662(US10077273, Compound 70 | US10584132, Compound 70 ...)
Affinity DataIC50: 1nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285662(US10077273, Compound 70 | US10584132, Compound 70 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285663(US10077273, Compound 11 | US10584132, Compound 11 ...)
Affinity DataIC50: 1.40nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285663(US10077273, Compound 11 | US10584132, Compound 11 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285664(US10077273, Compound 71 | US10584132, Compound 71 ...)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285664(US10077273, Compound 71 | US10584132, Compound 71 ...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285659(US10077273, Compound 68 | US10584132, Compound 68 ...)
Affinity DataIC50: 1.70nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285665(US10077273, Compound 72 | US10584132, Compound 72 ...)
Affinity DataIC50: 2nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285665(US10077273, Compound 72 | US10584132, Compound 72 ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285666(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Affinity DataIC50: 2nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285664(US10077273, Compound 71 | US10584132, Compound 71 ...)
Affinity DataIC50: 2.40nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285666(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Affinity DataIC50: 4nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285666(US10077273, Compound 2 | US10584132, Compound 2 | ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285665(US10077273, Compound 72 | US10584132, Compound 72 ...)
Affinity DataIC50: 4nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM485192(US10934305, Compound HK-16 (PK-2))
Affinity DataIC50: 5nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285688(US10077273, Compound HK-X2 | US10934305, Compound ...)
Affinity DataIC50: 5nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285667(US10077273, Compound 73 | US10584132, Compound 73 ...)
Affinity DataIC50: 7.5nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285667(US10077273, Compound 73 | US10584132, Compound 73 ...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285689(US10077273, Compound HK-X3 | US10934305, Compound ...)
Affinity DataIC50: 7.80nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 8nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285688(US10077273, Compound HK-X2 | US10934305, Compound ...)
Affinity DataIC50: 13nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285687(US10077273, Compound HK-X1 | US10934305, Compound ...)
Affinity DataIC50: 13nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285686(US10077273, Compound HK-16 | US10077273, Compound ...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285686(US10077273, Compound HK-16 | US10077273, Compound ...)
Affinity DataIC50: 15nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285689(US10077273, Compound HK-X3 | US10934305, Compound ...)
Affinity DataIC50: 16.9nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285669(US10077273, Compound 74 | US10584132, Compound 74 ...)
Affinity DataIC50: 17nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285669(US10077273, Compound 74 | US10584132, Compound 74 ...)
Affinity DataIC50: 19nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285669(US10077273, Compound 74 | US10584132, Compound 74 ...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285685(US10077273, Compound HK-15 | US10934305, Compound ...)
Affinity DataIC50: 20nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285686(US10077273, Compound HK-16 | US10077273, Compound ...)
Affinity DataIC50: 21nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285686(US10077273, Compound HK-16 | US10077273, Compound ...)
Affinity DataIC50: 27nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285685(US10077273, Compound HK-15 | US10934305, Compound ...)
Affinity DataIC50: 35nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285690(US10077273, Compound a | 6-amino-4-(3-bromo-5-(tri...)
Affinity DataIC50: 42nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 43nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285668(US10077273, Compound 8 | US10584132, Compound 8 | ...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285687(US10077273, Compound HK-X1 | US10934305, Compound ...)
Affinity DataIC50: 66nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
Go to US Patent

TargetSerine hydroxymethyltransferase, mitochondrial(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM285684(US10077273, Compound HK-14 | US10934305, Compound ...)
Affinity DataIC50: 67nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

Displayed 1 to 50 (of 158 total ) | Next | Last >>
Jump to: