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LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of high affinity neuronal GABA uptake by synaptosomes of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of rat GAT2 assessed as [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50021186(CHEMBL296263 | S(+)-4-amino-3-hydroxybutanoic acid...)
Affinity DataIC50: 2.90E+4nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039245(Dimethyl-[2-(1,7,7-trimethyl-2-phenyl-bicyclo[2.2....)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039234(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-pipe...)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039242(1-{2-[Bis-(4-chloro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039235(1-{2-[(4-Methoxy-phenyl)-di-p-tolyl-methoxy]-ethyl...)
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039238(1-{2-[Bis-(4-fluoro-phenyl)-(4-methoxy-phenyl)-met...)
Affinity DataIC50: 4.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of rat GAT-2 expressed in thymidine kinase deficient mouse LM cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2018
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of rat GAT2-mediated GABA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM90787(SMR000326834 | cid_11957555 | GUVACINE | MLS000859...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039240(1-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50021187(R(-)-4-amino-3-hydroxybutanoic acid | CHEMBL290216...)
Affinity DataIC50: 6.70E+4nMAssay Description:In vivo inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50021189(CHEMBL40804 | 5-Aminomethyl-4,5-dihydro-isoxazol-3...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vivo inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039236(1-{2-[Tris-(4-methoxy-phenyl)-methylsulfanyl]-ethy...)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039244(1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic...)
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039237(1-{3-[Tris-(4-methoxy-phenyl)-methoxy]-propyl}-pip...)
Affinity DataIC50: 1.03E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50225363(CHEMBL40363)
Affinity DataIC50: 1.30E+5nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039249(1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-...)
Affinity DataIC50: 1.37E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50021262(4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-5-ium-3-...)
Affinity DataIC50: 1.60E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039241(1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-...)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224812(CHEBI:35010 | CHEMBL170539)
Affinity DataIC50: 2.20E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50224810(CHEMBL171241)
Affinity DataIC50: 2.30E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039248((R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-...)
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM23183(CHEMBL273481 | Muscimol | 5-(aminomethyl)-1,2-oxaz...)
Affinity DataIC50: 3.20E+5nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224811(CHEMBL170753)
Affinity DataIC50: 4.00E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039252(1-{2-[(3-Fluoro-4-methoxy-phenyl)-(3-fluoro-phenyl...)
Affinity DataIC50: 4.17E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403565(CHEMBL2093978)
Affinity DataIC50: 4.47E+5nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned rat GAT-2 transporteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

LigandPNGBDBM50224808(CHEMBL309689)
Affinity DataIC50: 5.00E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50224809(CHEBI:34373 | Gaboxadol | LU-02030 | MK-0928)
Affinity DataIC50: 5.00E+5nMAssay Description:In vitro effect on GABA uptake in a crude preparation of synaptosomes from rat brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50021185(CHEMBL42464 | 5-Aminomethyl-4,5-dihydro-isoxazol-3...)
Affinity DataIC50: 5.00E+5nMAssay Description:In vitro inhibition of GABA uptake in rat brain synaptic membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50: 5.50E+5nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned rat GAT-2 transporteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020891((R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carbo...)
Affinity DataIC50: 5.50E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403566(CHEMBL2094022)
Affinity DataIC50: 6.69E+5nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned rat GAT-2 transporteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403563(CHEMBL2093977)
Affinity DataIC50: 7.57E+5nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned rat GAT-2 transporteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020888(CHEMBL77484 | (S)-nipecotic acid | (S)-Piperidine-...)
Affinity DataIC50: 7.63E+5nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50403564(CHEMBL2094024)
Affinity DataIC50: 8.10E+5nMAssay Description:Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned rat GAT-2 transporteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039253(1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piper...)
Affinity DataIC50: 3.67E+6nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 1.41E+6nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039247(1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-1,2,...)
Affinity DataIC50: 2.80E+6nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(CHEMBL542207 | CHEMBL77287 | 1-{2-[Bis-(4-trifluor...)
Affinity DataIC50: 1.28E+6nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed