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Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137538(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Affinity DataEC50:  277nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137540(2-Chloro-6-fluoro-N-[3-(1-methyl-piperidin-4-yl)-f...)
Affinity DataEC50:  69nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137539(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-fur...)
Affinity DataEC50:  92nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130448(N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]py...)
Affinity DataEC50:  36nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-HT1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130433(Cyclobutanecarboxylic acid [3-(1-methyl-piperidin-...)
Affinity DataEC50:  21nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130447(Thiophene-3-carboxylic acid [3-(1-methyl-piperidin...)
Affinity DataEC50:  9.40nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130442(Pyridine-2-carboxylic acid [3-(1-methyl-piperidin-...)
Affinity DataEC50:  25nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130420(Furan-2-carboxylic acid [3-(1-methyl-piperidin-4-y...)
Affinity DataEC50:  11nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130465(N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]py...)
Affinity DataEC50:  13nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130467(Thiophene-2-carboxylic acid [3-(1-methyl-piperidin...)
Affinity DataEC50:  15nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130437(N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]py...)
Affinity DataEC50:  11nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130426(N-[3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]py...)
Affinity DataEC50:  32nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130440(Cyclopropanecarboxylic acid [3-(1-methyl-piperidin...)
Affinity DataEC50:  34nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130439(Furan-3-carboxylic acid [3-(1-methyl-piperidin-4-y...)
Affinity DataEC50:  11nMAssay Description:In vitro effective concentration for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-)cells expressing the human 5-hydroxytryptamine 1F recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137541(4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b...)
Affinity DataEC50:  66nMAssay Description:Concentration required for stimulation of [35S]GTP-gamma-S, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50156403(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-2...)
Affinity DataEC50:  63nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50156406(2,4-Difluoro-N-[3-(1-methyl-piperidin-4-yl)-benzo[...)
Affinity DataEC50:  470nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50156408(2,4,6-Trifluoro-N-[3-(1-methyl-piperidin-4-yl)-2,3...)
Affinity DataEC50:  50nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50156409(2-Chloro-4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-b...)
Affinity DataEC50:  140nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding to cloned human 5-hydroxytryptamine 1F receptor expressed in Mouse LM(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50119543(CHEMBL3617549)
Affinity DataEC50:  87nMAssay Description:Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50119542(CHEMBL3617550)
Affinity DataEC50:  55nMAssay Description:Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50119532(CHEMBL3617557)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataEC50:  35nMAssay Description:In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50106482(N-[3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-y...)
Affinity DataEC50:  6nMAssay Description:In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  7.90nMAssay Description:In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50224303(CHEMBL283686)
Affinity DataKd:  8.40E+3nMAssay Description:Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligand, activity is expressed as Kd.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
LigandPNGBDBM50224302(CHEMBL31783)
Affinity DataKd:  43nMAssay Description:Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor using 1 uM LSD as masking ligand, activity is expressed as Kd.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
LigandPNGBDBM50224305(CHEMBL285355)
Affinity DataKd:  8.40E+3nMAssay Description:Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligand, activity is expressed as Kd.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573968(CHEMBL4851044)
Affinity DataIC50: 0.320nMAssay Description:Binding affinity to human 5HT1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573966(CHEMBL4847626)
Affinity DataIC50: 4.70nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573964(CHEMBL4846825)
Affinity DataIC50: 6.40nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573968(CHEMBL4851044)
Affinity DataIC50: 20nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573967(CHEMBL4865700)
Affinity DataIC50: 23nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573969(CHEMBL4860576)
Affinity DataIC50: 24nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573965(CHEMBL4862526)
Affinity DataIC50: 29nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573975(Lasmiditan | COL-144 | LY573144)
Affinity DataIC50: 88nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573970(CHEMBL4852743)
Affinity DataIC50: 161nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573971(CHEMBL4874958)
Affinity DataIC50: 178nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50473503(CHEMBL2110300)
Affinity DataIC50: 363nMAssay Description:Binding affinity towards human recombinant 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573972(CHEMBL4872571)
Affinity DataIC50: 571nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573973(CHEMBL4871295)
Affinity DataIC50: 813nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50005835(Sumax | 3-[2-(dimethylamino)ethyl]-N-methylindole-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50224302(CHEMBL31783)
Affinity DataIC50: 1.00E+3nMAssay Description:Ability to displace [3H]5-HT binding from 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
LigandPNGBDBM50224300(CHEMBL352315)
Affinity DataIC50: 2.24E+3nMAssay Description:Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50060437(3-(3-{4-[2-(3-Fluoro-phenyl)-ethyl]-piperazin-1-yl...)
Affinity DataIC50: 3.80E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50060429((R)-2-(4-Fluoro-phenyl)-2-{1-[3-(5-[1,2,4]triazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for the displacement of [3H]5-HT binding to cloned human 5-hydroxytryptamine 1F receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50573974(CHEMBL4861949)
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM50022539(CHEMBL14982)
Affinity DataIC50: 1.55E+4nMAssay Description:Stimulatory activity against serotonin secretion (SEC).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50022538(CHEMBL14651)
Affinity DataIC50: 1.82E+4nMAssay Description:Stimulatory activity against serotonin secretion (SEC).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50022537(CHEMBL14508)
Affinity DataIC50: 2.75E+4nMAssay Description:Stimulatory activity against serotonin secretion (SEC).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details Article
PubMed
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